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 115 <div class="style1" align="right">Download</div>
 116 </div>
 117 <div id="Layer2"
 118  style="position: absolute; left: 226px; width: 497px; z-index: 2; top: 188px; height: 877px;">
 119 <h3 class="heading1">Download</h3>
 120
 121 <p style="text-align: justify;">
 122
 123 PsN is distributed  as a gziped tar ball and zipped file. Both should work
 124 on Windows and UNIX (Including Linux an OS X).</p>
 125
 126 <table style="width: 100%;" border="0" cellpadding="4" cellspacing="4">
 127   <tbody>
 128 <!--    <tr>
 129       <td>
 130       <p><a href="http://prdownloads.sourceforge.net/psn/PsN-2.1.10.tar.gz?download" target="_blank">PsN-2.1.10.tar.gz</a></p>
 131       </td>
 132       <td>
 133       <p>This is the latest development release.</p>
 134       </td>
 135       <td>
 136       <p>2005-10-14</p>
 137       </td>
 138     </tr>
 139     <tr>
 140       <td>
 141       <p><a href="http://prdownloads.sourceforge.net/psn/PsN-2.1.10.zip?download" target="_blank">PsN-2.1.10.zip</a></p>
 142       </td>
 143       <td>
 144       <p>This is the latest development release.</p>
 145       </td>
 146       <td>
 147       <p>2005-10-14</p>
 148       </td>
 149     </tr> -->
 150     <tr>
 151       <td colspan="3">
 152       <p><b>Latest stable release</b></p>      </td>
 153     </tr>
 154
 155     <tr>
 156       <td colspan="3">
 157           <tr>
 158       <td width="27%"><p><a href="http://prdownloads.sourceforge.net/psn/PsN-2.2.5.tar.gz?download" target="_blank">PsN-2.2.5.tar.gz</a></p></td>
 159       <td width="55%">Please see the <a href="http://sourceforge.net/project/shownotes.php?group_id=101419&release_id=601480">change log</a> or the README.txt file for details. </td>
 160       <td width="18%"><p>2008-05-26</p></td>
 161     </tr>
 162     <tr>
 163       <td><p><a href="http://prdownloads.sourceforge.net/psn/PsN-2.2.5.zip?download" target="_blank">PsN-2.2.5.zip</a></p></td>
 164       <td><p>&nbsp;</p></td>
 165       <td><p>2008-05-26</p></td>
 166     </tr>
 167
 168     <tr>
 169       <td colspan="3">
 170       <p><b>Older releases</b></p></td>
 171     </tr>
 172
 173     <tr>
 174       <td colspan="3">
 175           <tr>
 176       <td width="27%"><p><a href="http://prdownloads.sourceforge.net/psn/PsN-2.2.4.tar.gz?download" target="_blank">PsN-2.2.4.tar.gz</a></p></td>
 177       <td width="55%">Please see the <a href="http://sourceforge.net/project/shownotes.php?group_id=101419&release_id=537859">change log</a> or the README.txt file for details. </td>
 178       <td width="18%"><p>2007-09-10</p></td>
 179     </tr>
 180     <tr>
 181       <td><p><a href="http://prdownloads.sourceforge.net/psn/PsN-2.2.4.zip?download" target="_blank">PsN-2.2.4.zip</a></p></td>
 182       <td><p>&nbsp;</p></td>
 183       <td><p>2007-09-10</p></td>
 184     </tr>
 185
 186     <tr>
 187       <td colspan="3">
 188           <tr>
 189       <td width="27%"><p><a href="http://prdownloads.sourceforge.net/psn/PsN-2.2.3.tar.gz?download" target="_blank">PsN-2.2.3.tar.gz</a></p></td>
 190       <td width="55%">Please see the <a href="http://sourceforge.net/project/shownotes.php?group_id=101419&release_id=504936">change log</a> or the README.txt file for details. </td>
 191       <td width="18%"><p>2007-04-30</p></td>
 192     </tr>
 193     <tr>
 194       <td><p><a href="http://prdownloads.sourceforge.net/psn/PsN-2.2.3.zip?download" target="_blank">PsN-2.2.3.zip</a></p></td>
 195       <td><p>&nbsp;</p></td>
 196       <td><p>2007-04-30</p></td>
 197     </tr>
 198     <tr>
 199       <td><p><a href="http://prdownloads.sourceforge.net/psn/PsN-2.2.2.tar.gz?download" target="_blank">PsN-2.2.2.tar.gz</a></p></td>
 200       <td>Includes a rather large re-write of the jobs submission. Memory foot print should be much lower.  See the README.txt for details.</td>
 201       <td><p>2007-03-05</p></td>
 202     </tr>
 203     <tr>
 204       <td><p><a href="http://prdownloads.sourceforge.net/psn/PsN-2.2.2.zip?download" target="_blank">PsN-2.2.2.zip</a></p></td>
 205       <td><p>&nbsp;</p></td>
 206       <td><p>2007-03-05</p></td>
 207     </tr>
 208     <tr>
 209       <td colspan="3">
 210           <tr>
 211         <td><p><a href="http://prdownloads.sourceforge.net/psn/PsN-2.2.1.tar.gz?download" target="_blank">PsN-2.2.1.tar.gz</a></p></td>
 212             <td><p>Version 2.2.1</p></td>
 213             <td><p>2006-11-07</p></td>
 214       </tr>
 215           <tr>
 216         <td><p><a href="http://prdownloads.sourceforge.net/psn/PsN-2.2.1.zip?download" target="_blank">PsN-2.2.1.zip</a></p></td>
 217             <td><p>&nbsp;</p></td>
 218             <td><p>2006-11-07</p></td>
 219       </tr>
 220           <tr>
 221         <td><p><a href="http://prdownloads.sourceforge.net/psn/PsN-2.2.0.tar.gz?download" target="_blank">PsN-2.2.0.tar.gz</a></p></td>
 222             <td><p>The new 2.2.0 release</p></td>
 223             <td><p>2006-08-09</p></td>
 224       </tr>
 225           <tr>
 226         <td><p><a href="http://prdownloads.sourceforge.net/psn/PsN-2.2.0.zip?download" target="_blank">PsN-2.2.0.zip</a></p></td>
 227             <td><p>&nbsp;</p></td>
 228             <td><p>2006-08-09</p></td>
 229       </tr>
 230
 231
 232     <tr>
 233       <td colspan="3" style="vertical-align: top;"><p>&nbsp;</p></td>
 234     </tr>
 235     <tr>
 236       <td colspan="3">
 237       <p><b>Beta releases</b></p></td>
 238     </tr>
 239     <tr>
 240       <td colspan="3">
 241           <tr>
 242         <td colspan="3" style="vertical-align: top;"><p>We have begun to release beta tests of the stable releases. In these we will include all bug fixes and feature additions  that we think are suitable to add quickly to the stable branch. </p></td>
 243       </tr>
 244           <tr>
 245       <td><p><a href="http://prdownloads.sourceforge.net/psn/PsN-2.2.2-beta4.tar.gz?download" target="_blank">PsN-2.2.2-beta4.tar.gz</a></p></td>
 246       <td><p>4:th beta of the 2.2.2 release. Please use the stable release 2.2.3. It is newer than this beta release. </p></td>
 247       <td><p>2007-01-29</p></td>
 248     </tr>
 249     <tr>
 250       <td><p><a href="http://prdownloads.sourceforge.net/psn/PsN-2.2.2-beta4.zip?download" target="_blank">PsN-2.2.2-beta4.zip</a></p></td>
 251       <td><p>&nbsp;</p></td>
 252       <td><p>2007-01-29</p></td>
 253     </tr>
 254     <tr>
 255       <td colspan="3" style="vertical-align: top;"><p>&nbsp;</p></td>
 256     </tr>
 257     <tr>
 258       <td colspan="3" style="vertical-align: top;"><p><b>PsN Development release</b></p></td>
 259     </tr>
 260     <tr>
 261       <td colspan="3" style="vertical-align: top;"><p>There is currently no development version available, but we are
 262           planning to implement some interresting features and a release
 263           of 2.3.0 might appear here then.</p></td>
 264     </tr>
 265   </tbody>
 266 </table>
 267
 268 <p>&nbsp;</p>
 269 <h3 class="heading1">Version numbers</h3>
 270
 271 <p style="text-align: justify;">
 272
 273 The PsN project follows the Linux style version numbering. The format
 274 is X.Y.Z where X is major version. The Y is minor version and
 275 increases when significant features are added or changed. The minor
 276 version is even for stable release, and odd for development
 277 releases. The Z is a revision number, it changes more often and
 278 signifies smaller changes, mostly bug fixes.<br> </p>
 279
 280 <p style="text-align: justify;">
 281
 282 Older PsN versions is available from the <a target="_blank"
 283 href="http://sourceforge.net/projects/psn/">SourceForge project
 284 page</a>. (Look under the <a
 285 href="http://sourceforge.net/project/showfiles.php?group_id=101419">files</a>
 286 section). The project page also explains how to access the SourceForge
 287 CVS, the repository where the latest changes to PsN are stored. However, if you
 288 download PsN from the CVS the stability is not guaranteed - it might
 289 be broken. </p>
 290
 291 <h3 class="heading1">Compatibility<br> </h3>
 292
 293 <p align="justify">PsN is tested on various platfiorms.
 294 <table width="499" border="1">
 295   <tr>
 296     <th scope="col">&nbsp;</th>
 297     <th scope="col">Operating system version </th>
 298     <th scope="col">Perl</th>
 299     <th scope="col">NONMEM</th>
 300     <th scope="col">Fortran compiler </th>
 301   </tr>
 302   <tr>
 303     <th scope="row">Microsoft Windows</th>
 304     <td>XP</td>
 305     <td><a target="_blank"
 306  href="http://www.activestate.com/Products/ActivePerl/">ActiveState</a> ActivePerl 5.6.8.811 and 5.8.8.819 </td>
 307     <td>5 and 6 </td>
 308     <td><a
 309 target="_blank" href="http://www.qtsoftware.de/dvf/">Digital Visual
 310   Fortran</a> version 6.5 </td>
 311   </tr>
 312   <tr>
 313     <th scope="row">&nbsp;</th>
 314     <td>2000</td>
 315     <td><a target="_blank"
 316  href="http://www.activestate.com/Products/ActivePerl/">ActiveState</a> ActivePerl 5.6.8.811 and 5.8.8.819 </td>
 317     <td>5 and 6</td>
 318     <td><a
 319 target="_blank" href="http://www.qtsoftware.de/dvf/">Digital Visual
 320   Fortran</a> version 6.5</td>
 321   </tr>
 322   <tr>
 323     <th scope="row">Macintosh</th>
 324     <td>OS X 10.4.7 and above </td>
 325     <td>5.8.6 and 5.8.8</td>
 326     <td>5 and 6</td>
 327     <td>Intel Fortran 9.1 </td>
 328   </tr>
 329   <tr>
 330     <th scope="row">Linux</th>
 331     <td>Red Hat 9, Gentoo </td>
 332     <td>&nbsp;</td>
 333     <td>5 and 6</td>
 334     <td><a target="_blank"
 335 href="http://www.gnu.org">GNU</a> g77 2.96 and 3.3 </td>
 336   </tr>
 337   <tr>
 338     <th scope="row">&nbsp;</th>
 339     <td>&nbsp;</td>
 340     <td>&nbsp;</td>
 341     <td>&nbsp;</td>
 342     <td>&nbsp;</td>
 343   </tr>
 344 </table>
 345 <p align="justify">
 346
 347 <p align="justify">
 348
 349 Our aim is to make PsN platform independent. Please try
 350 PsN on other platforms and with other Perl versions and compilers and
 351 report your success or failure.
 352 <h3 class="heading1">Installation instructions<br> </h3>
 353
 354 <p>Installation is easy and consists of five simple
 355 steps.</p>
 356
 357 <p style="font-weight: bold;">Installation using the provided setup
 358 script</p> <ol>
 359   <li>
 360     <p>Unpack the file you downloaded. It will create a directory
 361        called <tt>PsN-Source.</tt></p>
 362   </li>
 363   <li>
 364     <div style="text-align: justify;">
 365
 366     <p align="justify">Run the installation script from within <tt>PsN-Source</tt>.
 367        If you are running windows and have <a target="_blank"
 368  href="http://www.activestate.com/Products/ActivePerl/">ActiveState
 369       ActivePerl</a> installed you should be able to double-click on
 370       <tt>setup.pl</tt>. Otherwise open a command line window (Windows Start-&gt;Run, type 'cmd'), go to
 371       the <tt>PsN-Source </tt>directory and type: </p>
 372     </div>
 373     <p><tt>perl setup.pl</tt></p>
 374     <p>Unix users should open their favorite terminal go to the <tt>PsN-Source</tt> directory and type: </p>
 375     <p><tt>perl setup.pl</tt></p>
 376   </li>
 377   <li style="text-align: justify;">
 378
 379     <p>Answer the questions on screen. The default is probably the
 380        best for most users. If you cannot install PsN where the install
 381        script suggests and you wish to use PsN in your own perl
 382        scripts, you must make sure that the directory where you
 383        installed the PsN core and toolkit is in Perl's include
 384        path. For convenience you should also check that the directory
 385        where the utilities are installed is in your search path.      </p>
 386   </li>
 387   <li>
 388
 389     <p style="text-align: justify;">Edit the configuration file    <tt>psn.conf</tt> to make PsN aware your NONMEM
 390     installation. If you accept the default options in the PsN setup script, this file is usually found in C:\Perl\site\lib\PsN_version_number\ (Windows) or /usr/local/lib/perl5/site_perl/perl_version/PsN_version/ or /usr/lib/perl5/site_perl/perl_version/PsN_version/ (Linux and Macintosh). </p> <p> For a more detailed documentation of the psn.conf <a href="psn_conf.php">look here.</a></p>
 391
 392     <p><span style="font-family: monospace;">[nm_versions]</span><br style="font-family: monospace;">
 393       <span style="font-family: monospace;">default=/export/home/nmvi1.0,6 <br style="font-family: monospace;">
 394 5=/export/home/nmv1.1,5
 395       <br style="font-family: monospace;">
 396 5_big=/export/home/nmv1.1_big,5</span><br>
 397       <span style="font-family: monospace;">6=/export/home/nmvi1.0</span> <br style="font-family: monospace;">
 398       <span style="font-family: monospace;"></span><br style="font-family: monospace;">
 399       <span style="font-family: monospace;">[compiler]</span>
 400       <br style="font-family: monospace;">
 401       <span style="font-family: monospace;">; Gnu fortran compiler</span>
 402       <br style="font-family: monospace;">
 403       <span style="font-family: monospace;">name=g77</span>
 404       <br style="font-family: monospace;">
 405       <span style="font-family: monospace;">options=-W -static -O</span> </p>
 406   </li>
 407   <li><div style="text-align: justify;">
 408       <p>The header <tt>[nm_versions]</tt> must always be present. Each
 409         line under the <tt>nm_version</tt> header corresponds to a NONMEM version. To
 410         the left of the equal sign is an  identifier which is a number
 411         or a text that names an installation of NONMEM. This is what you give to the PsN utilities using the option <tt>-nm_version</tt>.
 412         Next comes the directory where the version of NONMEM is installed. Last is a version number. This is new from PsN version 2.2.2 and is needed for the computation of conditional weighted residuals. </p>
 413
 414     <p>The <tt>[compiler]</tt> section is optional but necessary if you have
 415       another compiler than g77. The <tt>compiler</tt> section has two
 416       lines. One starting with <tt>name</tt> on the left of the equal sign
 417       which is the compiler executable name. You should include a path if you
 418       don't have the compiler directory in you environment path. The second
 419       line is the <tt>options</tt> line where you specify compiler options,
 420       such as optimizations. (Note that
 421       lines starting with ; are ignored.)</p>
 422   </div>
 423   </li>
 424   <li>When the installation is
 425         done you can safely remove the <tt>PsN-Source</tt>
 426     directory if you like.</li>
 427   </ol>
 428 <br>
 429 <p style="font-weight: bold;">Manual installation</p>
 430 <p></p>
 431
 432 <p><b> As of version 2.2 we strongly encourage use of the installation
 433 script, it is stable and should work fine for most people. Should it
 434 fail for you, or have problems with installing an older PsN version, please contact us.</b> </p>
 435 <!--
 436  <ol>
 437   <li>
 438     <p>Unpack the file you downloaded. It will create a directory
 439 called <tt>PsN-Source.</tt></p>
 440   </li>
 441   <li>
 442     <p align="justify">Copy the <tt>PsN-Source\lib</tt> to a directory which is in the
 443 Perl include path. Make sure you name the directory <tt>PsN</tt>. Then
 444 copy the contents of <tt>PsN-Source\bin</tt> to a place that is in
 445 your systems path.
 446
 447 On my Windows installation of Perl I place the <tt>PsN-Source\lib</tt>
 448 directory in <tt>C:\perl\site\lib</tt>. And the contents of
 449 <tt>PsN-Source\bin</tt> in <tt>C:\perl\bin</tt>.
 450
 451 <p align="justify"> To get the Windows command line to recognize that the programs you
 452 just copied to <tt>C:\perl\bin</tt> you must create a batch file for
 453 each program. The easiest way is to just copy the <tt>runperl.bat</tt>
 454 that comes with ActiveState's Perl distribution. Make one copy for each
 455 program with the same name as the program but with the <tt>.bat</tt>
 456 extension.
 457 <p align="justify">
 458 For example, on a Gentoo Linux installation of Perl a good spot to place the
 459 <tt>PsN-Source\lib</tt> directory is in
 460 <tt>/usr/lib/perl5/site_perl/5.8.5</tt> and the
 461 <tt>PsN-Source\bin</tt> contents in <tt>/usr/bin</tt>
 462
 463     </p>
 464   </li>
 465   <li>
 466     <p align="justify">Next you must copy <span style="font-family:
 467 monospace;">PsN.pm</span> from the <tt>PsN-Source\lib</tt> to the
 468 directory just above the <tt>PsN</tt> you just created. Then you must
 469 edit it to find the PsN directory. The file looks something like this.<p align="justify">
 470
 471
 472 <span style="font-family: monospace;">package PsN;</span>
 473 <br style="font-family: monospace;">
 474 <span style="font-family: monospace;">use lib 'c:\perl\site\lib\PsN';</span>
 475 <br style="font-family: monospace;">
 476 <span style="font-family: monospace;">$config_file = "c:\perl\site\lib\PsN\psn.conf';</span>
 477 <br style="font-family: monospace;">
 478 <span style="font-family: monospace;">1;</span>
 479 <p align="justify">
 480 Now change the paths to where you installed PsN.<br>
 481     </p>
 482   </li>
 483   <li>
 484     <p align="justify">Edit the configuration, in the same way as in automatic
 485 installation.</p>
 486   </li>
 487   <li>
 488     <p align="justify">Install extra packages. At the time of writing, they are:</p>
 489   </li>
 490   <div align="justify">
 491
 492      <ul>
 493          <li> <a target="_blank"
 494  href="http://search.cpan.org/%7Egrommel/Math-Random-0.67/">Math::Random-0.67</a></li>
 495          <li><a target="_blank"
 496  href="http://search.cpan.org/%7Eams/Storable-2.13/">Storable::Store-0.67</a> (included with ActiveState Perl for Windows.)
 497         </li>
 498       </ul>
 499        <p align="justify">All are available from <a target="_blank"
 500  href="http://www.cpan.org/">CPAN.</a></p>
 501       </li>
 502   </div>
 503   <div align="justify"><li>When the installation is done you can safely remove the <tt>PsN-Source</tt>
 504 directory if you like.</div>
 505     </li>
 506   </ol>
 507 -->
 508 <p>&nbsp;</p>
 509 </div>
 510 <table border="0" cellpadding="0" cellspacing="0" width="780">
 511   <tbody>
 512     <tr>
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