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 115 <div class="style1" align="right">Introduction</div>
 116 </div>
 117 <div id="Layer2"
 118  style="position: absolute; left: 226px; top: 188px; width: 497px; height: 431px; z-index: 2;">
 119 <h3 class="heading1">Perl-speaks-NONMEM</h3>
 120 <p style="text-align: justify;">
 121 Our work to bring Perl-speaks-NONMEM (PsN) into version 2 has
 122 necessitated some changes, and some additions. PsN has been logically
 123 divided into three parts. You still download and install one package.
 124 </p>
 125 <p style="text-align: justify;">What was known as PsN before is now
 126 called <b>PsN
 127 Core</b>. The core
 128 modules of PsN are built around NONMEM's model, data and output
 129 files. It is object-oriented and includes modules that can be used as
 130 building blocks for specialized scripts. The function of these modules
 131 include parameter estimate extraction from output files, data file
 132 subsetting and setting of model initial estimates with values from an
 133 output file.
 134 </p>
 135 <p style="text-align: justify;">On top of PsN Core we have implemented <b>PsN
 136 Toolkit</b>, a collection
 137 of statistical tools and algorithms for model-building. Collectively we
 138 call them tools, hence the name Toolkit. Each tool is implemented as a
 139 Perl class. Use of a tool from the Toolkit requires some basic
 140 knowledge of Perl and some understanding of the Toolkit framework.
 141 </p>
 142 <p style="text-align: justify;">The third part, implemented on top of
 143 the Toolkit and the
 144 Core, is <b>PsN Utilities</b>. The Utilities are a set of command line
 145 programs that allows a user to run the tools in the Toolkit. Also
 146 there are utilities that perform simpler tasks, such as sumarizing the
 147 NONMEM output. <b>Using the Utilities requires no perl knowledge.</b>
 148 </p>
 149 <p style="text-align: justify;">Read more about the different parts
 150 under <a href="docs.php">Documents</a>.
 151 </p>
 152 <p style="text-align: justify;"><a target="_blank"
 153  href="http://www.perl.org/">Perl</a>
 154 is a free, multi-platform scripting language that was originally
 155 designed for handling text files. Since NONMEM is used on many
 156 different computer platforms and uses text files for all its input and
 157 output, perl is the ideal language for the kind of programs outlined
 158 above.
 159 </p>
 160 <p style="text-align: justify;">Perl-speaks-NONMEM is copyright &copy;
 161 2000-2004 by <a href="mailto:lars.lindbom@farmbio.uu.se">Lars Lindbom</a>
 162 and <a href="mailto:niclas.jonsson@farmbio.uu.se">Niclas
 163 Jonsson</a>. All rights reserved.
 164 </p>
 165 <p style="text-align: justify;">PsN is maintained by <a
 166  href="mailto:pontus.pihlgren@farmbio.uu.se">Pontus
 167 Pihlgren</a> and <a href="mailto:lars.lindbom@farmbio.uu.se">Lars
 168 Lindbom</a>.
 169 </p>
 170 <p style="text-align: justify;">Site designed and implemented
 171 by <a href="mailto:justin.wilkins@farmbio.uu.se">Justin
 172 Wilkins</a>.
 173 </p>
 174 <p style="text-align: justify;">Perl-speaks-NONMEM is licensed under
 175 version 2 of the GNU General
 176 Public License as published by the Free Software Foundation.
 177 </p>
 178 <h3 style="text-align: justify;" class="heading1">Acknowledgments</h3>
 179 <p style="text-align: justify;">NONMEM&reg; is a registered trademark
 180 of GloboMax. The Perl camel
 181 logo is
 182 a registered trademark of O'Reilly Media, Inc. and is used with
 183 permission. All logos and trademarks in this site are property of
 184 their respective owners.
 185 </p>
 186 <div style="text-align: justify;"></div>
 187 <p style="text-align: justify;">&nbsp;</p>
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