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  76 <div class="style1" align="right">Welcome</div>
  77 </div>
  78 <div id="Layer2"
  79  style="position: absolute; left: 226px; top: 188px; width: 497px; height: 431px; z-index: 2;">
  80 <div align="justify">
  81 <h3 class="heading1">Latest News</h3>
  82 <p>Version 2.2.4 is available <a href="http://sourceforge.net/project/showfiles.php?group_id=101419">here</a>.</p>
  83 <p>New features</p>
  84 <p>- Simulated data suitable for creating mirror plots can be generated
  85    by using a new options called --mirror_plots. The option takes a
  86    value which defines the number of simulations that will be
  87    generated.</p>
  88 <p>- A new option, --iofv, enables the computation of individual
  89    objective function values. These values are printed to a table file
  90    called iotab*, where * is the same number as is defined for any
  91    sdtab or patab tables. These names correspond to the normal Xpose
  92    table file format. If no sdtab or patab table is found in the
  93    NONMEM control stream, the iotab file is given number 1. </p>
  94 <p>- A brand new user command <tt>update_inits</tt> that will put
  95    final estimates from a NONMEM output file and put into a given
  96    model file. This is quite experimental. PsN will reformat the model
  97    file quite a lot and comments in the file might get lost. Your model
  98    file will be copied with the addition of a ".org" extension, so you
  99    wont lose your model.</p>
 100 <p>- "--compute_cwres" option renamed to simply "--cwres"</p>
 101
 102 <p>Bug Fixes  </p>
 103 <p>- As usual a few bugs were found and fixed between 2.2.3 and 2.2.4. Please read the <a href="http://sourceforge.net/project/shownotes.php?group_id=101419&release_id=537859">change logs</a>. These are also available in the README.txt file included in the release packege as usual. The most important bug fixes are that PsN now works properly on Windows 2000 and fixes to the Sun Grid Engine interface(Thanks to Jeroen Elassaiss and Stefan Verhoeven). </p>
 104 <p><span class="heading1">Perl-speaks-NONMEM</span></p>
 105 <p>Perl-speaks-NONMEM (PsN) is a collection of Perl modules and programs aiding in the development
 106   of non-linear mixed effect models using NONMEM. The functionality ranges from solutions to simpler
 107   tasks such as parameter estimate extraction from output files, data file sub setting  and resampling,
 108   to advanced computer-intensive statistical methods. PsN includes stand-alone tools for the end-user
 109   as well as development libraries for method developers.
 110 </p>
 111 <p>
 112   Compared to previous versions of PsN 2, the ongoing work on PsN version 2.2 has brought some changes
 113   to the overall structure. PsN is now logically divided into three parts. Note, however, that you still
 114   only download and install one package.
 115 </p>
 116 <p>
 117 Most of what was included in the 2.0 release of PsN is now included in <b>PsN-Core</b>. PsN-Core is built around NONMEM's model, data and output
 118 files.  Through PsN-Core
 119 all parts of these files can be controlled in user-written Perl code. </p>
 120 <p>
 121 Using the functionality of PsN-Core we have implemented two new components: <strong>PsN-Toolkit</strong> and <strong>PsN-Utilities</strong>.</p>
 122 <p><strong>PsN-Toolkit</strong> is a collection
 123   of computer intensive statistical methods for non-linear mixed effect modeling using NONMEM.  The toolkit includes Perl modules for Bootstrapping, Jackknifing, Log-likelihood Profiling, Case-deletion Diagnostics and Stepwise Covariate Model building. Using  a module from PsN-Toolkit requires some basic
 124   knowledge of Perl and some understanding of the toolkit framework. </p>
 125 <p><b>PsN-Utilities</b> is a set of command line programs
 126 that allows the user to use the functionality of PsN-Core and PsN-Toolkit without the need to write Perl code. Apart from programs for all the tools in PsN-Toolkit, PsN-Utilities includes utilities that perform simpler tasks, such as summarizing the output from NONMEM
 127 runs.
 128 </p>
 129 <p>You can read more about the different parts under <a href="docs.php">Documentation</a>.</p>
 130 <p>
 131 Perl-speaks-NONMEM is copyright &copy; 2000-2005 by <a href="mailto:lars.lindbom@farmbio.uu.se">Lars Lindbom</a>
 132 and <a href="mailto:niclas.jonsson@farmbio.uu.se">Niclas
 133 Jonsson</a> and 2006-2007 by Lars Lindbom. All rights reserved.
 134 </p>
 135 <p>
 136 PsN is maintained by <a href="mailto:pontus.pihlgren@farmbio.uu.se">Pontus
 137 Pihlgren</a> and <a href="mailto:lars.lindbom@farmbio.uu.se">Lars
 138 Lindbom</a>.
 139 </p>
 140 <p>The site is designed and implemented
 141 by <a href="mailto:justin.wilkins@farmbio.uu.se">Justin
 142 Wilkins</a>.
 143 </p>
 144 <p>
 145 Perl-speaks-NONMEM is licensed under version 2 of the GNU General
 146 Public License as published by the Free Software Foundation.
 147 </p>
 148 <h3 class="heading1">References</h3>
 149 <ul>
 150     <li class="reference"> <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=
 151 16023764&query_hl=1&itool=pubmed_docsum">Lindbom L, Pihlgren P, Jonsson EN.</a> <br>
 152                 PsN-Toolkit--a collection of computer intensive statistical methods for non-linear mixed effect modeling using NON
 153 MEM. <br>
 154                 Comput Methods Programs Biomed. 2005 Sep;79(3):241-57. </li>
 155     <li class="reference"> <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=
 156 15212851&query_hl=1&itool=pubmed_docsum">Lindbom L, Ribbing J, Jonsson EN. </a> <br>
 157                 Perl-speaks-NONMEM (PsN)--a Perl module for NONMEM related programming.<br>
 158         Comput Methods Programs Biomed. 2004 Aug;75(2):85-94.</li>
 159 </ul>
 160
 161   <h3 class="heading1">Acknowledgments</h3>
 162 <p>
 163 NONMEM&reg; is a registered trademark of GloboMax. The Perl camel
 164 logo is
 165 a registered trademark of O'Reilly Media, Inc. and is used with
 166 permission. All logos and trademarks in this site are property of
 167 their respective owners.
 168 </p>
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 172     <td width="80%">PsN is hosted at SourceForge. </td>
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 175 <p>&nbsp;</p>
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