| blob | 4e9e370d54145087b4c2dd75625f4e09d24f3d68 |
1 LOCUS NC_002058 7440 bp ss-RNA linear VRL 08-DEC-2008
2 DEFINITION Poliovirus, complete genome.
3 ACCESSION NC_002058
4 VERSION NC_002058.3 GI:12408699
5 DBLINK BioProject: PRJNA15288
6 DBLINK Project:100,200,300
7 DBLINK NC_002058.3
8 KEYWORDS coat protein; complementary DNA; genome; polyprotein.
9 SOURCE Human enterovirus C
10 ORGANISM Human enterovirus C
11 Viruses; ssRNA positive-strand viruses, no DNA stage;
12 Picornavirales; Picornaviridae; Enterovirus.
13 REFERENCE 1 (sites)
14 AUTHORS Dorner,A.J., Dorner,L.F., Larsen,G.R., Wimmer,E. and Anderson,C.W.
15 TITLE Identification of the initiation site of poliovirus polyprotein
16 synthesis
17 JOURNAL J. Virol. 42 (3), 1017-1028 (1982)
18 PUBMED 6284987
19 REFERENCE 2 (sites)
20 AUTHORS Emini,E.A., Elzinga,M. and Wimmer,E.
21 TITLE Carboxy-terminal analysis of poliovirus proteins: termination of
22 poliovirus RNA translation and location of unique poliovirus
23 polyprotein cleavage sites
24 JOURNAL J. Virol. 42 (1), 194-199 (1982)
25 PUBMED 6283138
26 REFERENCE 3 (bases 1 to 7440)
27 AUTHORS Racaniello,V.R. and Baltimore,D.
28 TITLE Molecular cloning of poliovirus cDNA and determination of the
29 complete nucleotide sequence of the viral genome
30 JOURNAL Proc. Natl. Acad. Sci. U.S.A. 78 (8), 4887-4891 (1981)
31 PUBMED 6272282
32 REFERENCE 4 (bases 1 to 7440)
33 AUTHORS Kitamura,N., Semler,B.L., Rothberg,P.G., Larsen,G.R., Adler,C.J.,
34 Dorner,A.J., Emini,E.A., Hanecak,R., Lee,J.J., van der Werf,S.,
35 Anderson,C.W. and Wimmer,E.
36 TITLE Primary structure, gene organization and polypeptide expression of
37 poliovirus RNA
38 JOURNAL Nature 291 (5816), 547-553 (1981)
39 PUBMED 6264310
40 REFERENCE 5 (bases 5360 to 5527)
41 AUTHORS Kitamura,N., Adler,C.J., Rothberg,P.G., Martinko,J., Nathenson,S.G.
42 and Wimmer,E.
43 TITLE The genome-linked protein of picornaviruses. VII. Genetic mapping
44 of poliovirus VPg by protein and RNA sequence studies
45 JOURNAL Cell 21 (1), 295-302 (1980)
46 PUBMED 6250717
47 REFERENCE 6 (bases 6383 to 7440)
48 AUTHORS Kitamura,N. and Wimmer,E.
49 TITLE Sequence of 1060 3'-terminal nucleotides of poliovirus RNA as
50 determined by a modification of the dideoxynucleotide method
51 JOURNAL Proc. Natl. Acad. Sci. U.S.A. 77 (6), 3196-3200 (1980)
52 PUBMED 6158042
53 REFERENCE 7 (bases 1 to 7440)
54 CONSRTM NCBI Genome Project
55 TITLE Direct Submission
56 JOURNAL Submitted (01-AUG-2000) National Center for Biotechnology
57 Information, NIH, Bethesda, MD 20894, USA
58 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
59 reference sequence was derived from V01149.
60 On Jan 24, 2001 this sequence version replaced gi:12331600.
61 See also entries V01148 (POLIO1A, for another version of this
62 genome) and V01150 (POLIOS1, for the genome of the Sabin 1 strain).
63 See the entry V01148 (POLIO1A) for the sequence reported in [3].
64 Mature peptides were added to the annotation by NCBI RefSeq Genomes
65 staff.
66 COMPLETENESS: full length.
67 FEATURES Location/Qualifiers
68 source 1..7440
69 /organism="Human enterovirus C"
70 /mol_type="genomic RNA"
71 /strain="Human poliovirus 1 Mahoney"
72 /db_xref="taxon:138950"
73 conflict 284..288
74 /note="CGCUC is GUU in [3]"
75 /citation=[4]
76 conflict 352
77 /note="G is U in [3]"
78 /citation=[4]
79 conflict 387
80 /note="GC is C in [3]"
81 /citation=[4]
82 conflict 488
83 /note="G is GU in [3]"
84 /citation=[4]
85 gene 743..7372
86 /locus_tag="PVgp1"
87 /db_xref="GeneID:919920"
88 CDS 743..7372
89 /locus_tag="PVgp1"
90 /codon_start=1
91 /product="polyprotein"
92 /protein_id="NP_041277.1"
93 /db_xref="GI:9627037"
94 /db_xref="GOA:P03300"
95 /db_xref="UniProtKB/Swiss-Prot:P03300"
96 /db_xref="GeneID:919920"
97 /translation="MGAQVSSQKVGAHENSNRAYGGSTINYTTINYYRDSASNAASKQ
98 DFSQDPSKFTEPIKDVLIKTAPMLNSPNIEACGYSDRVLQLTLGNSTITTQEAANSVV
99 AYGRWPEYLRDSEANPVDQPTEPDVAACRFYTLDTVSWTKESRGWWWKLPDALRDMGL
100 FGQNMYYHYLGRSGYTVHVQCNASKFHQGALGVFAVPEMCLAGDSNTTTMHTSYQNAN
101 PGEKGGTFTGTFTPDNNQTSPARRFCPVDYLLGNGTLLGNAFVFPHQIINLRTNNCAT
102 LVLPYVNSLSIDSMVKHNNWGIAILPLAPLNFASESSPEIPITLTIAPMCCEFNGLRN
103 ITLPRLQGLPVMNTPGSNQYLTADNFQSPCALPEFDVTPPIDIPGEVKNMMELAEIDT
104 MIPFDLSATKKNTMEMYRVRLSDKPHTDDPILCLSLSPASDPRLSHTMLGEILNYYTH
105 WAGSLKFTFLFCGFMMATGKLLVSYAPPGADPPKKRKEAMLGTHVIWDIGLQSSCTMV
106 VPWISNTTYRQTIDDSFTEGGYISVFYQTRIVVPLSTPREMDILGFVSACNDFSVRLL
107 RDTTHIEQKALAQGLGQMLESMIDNTVRETVGAATSRDALPNTEASGPTHSKEIPALT
108 AVETGATNPLVPSDTVQTRHVVQHRSRSESSIESFFARGACVTIMTVDNPASTTNKDK
109 LFAVWKITYKDTVQLRRKLEFFTYSRFDMELTFVVTANFTETNNGHALNQVYQIMYVP
110 PGAPVPEKWDDYTWQTSSNPSIFYTYGTAPARISVPYVGISNAYSHFYDGFSKVPLKD
111 QSAALGDSLYGAASLNDFGILAVRVVNDHNPTKVTSKIRVYLKPKHIRVWCPRPPRAV
112 AYYGPGVDYKDGTLTPLSTKDLTTYGFGHQNKAVYTAGYKICNYHLATQDDLQNAVNV
113 MWSRDLLVTESRAQGTDSIARCNCNAGVYYCESRRKYYPVSFVGPTFQYMEANNYYPA
114 RYQSHMLIGHGFASPGDCGGILRCHHGVIGIITAGGEGLVAFSDIRDLYAYEEEAMEQ
115 GITNYIESLGAAFGSGFTQQISDKITELTNMVTSTITEKLLKNLIKIISSLVIITRNY
116 EDTTTVLATLALLGCDASPWQWLRKKACDVLEIPYVIKQGDSWLKKFTEACNAAKGLE
117 WVSNKISKFIDWLKEKIIPQARDKLEFVTKLRQLEMLENQISTIHQSCPSQEHQEILF
118 NNVRWLSIQSKRFAPLYAVEAKRIQKLEHTINNYIQFKSKHRIEPVCLLVHGSPGTGK
119 SVATNLIARAIAERENTSTYSLPPDPSHFDGYKQQGVVIMDDLNQNPDGADMKLFCQM
120 VSTVEFIPPMASLEEKGILFTSNYVLASTNSSRISPPTVAHSDALARRFAFDMDIQVM
121 NEYSRDGKLNMAMATEMCKNCHQPANFKRCCPLVCGKAIQLMDKSSRVRYSIDQITTM
122 IINERNRRSNIGNCMEALFQGPLQYKDLKIDIKTSPPPECINDLLQAVDSQEVRDYCE
123 KKGWIVNITSQVQTERNINRAMTILQAVTTFAAVAGVVYVMYKLFAGHQGAYTGLPNK
124 KPNVPTIRTAKVQGPGFDYAVAMAKRNIVTATTSKGEFTMLGVHDNVAILPTHASPGE
125 SIVIDGKEVEILDAKALEDQAGTNLEITIITLKRNEKFRDIRPHIPTQITETNDGVLI
126 VNTSKYPNMYVPVGAVTEQGYLNLGGRQTARTLMYNFPTRAGQCGGVITCTGKVIGMH
127 VGGNGSHGFAAALKRSYFTQSQGEIQWMRPSKEVGYPIINAPSKTKLEPSAFHYVFEG
128 VKEPAVLTKNDPRLKTDFEEAIFSKYVGNKITEVDEYMKEAVDHYAGQLMSLDINTEQ
129 MCLEDAMYGTDGLEALDLSTSAGYPYVAMGKKKRDILNKQTRDTKEMQKLLDTYGINL
130 PLVTYVKDELRSKTKVEQGKSRLIEASSLNDSVAMRMAFGNLYAAFHKNPGVITGSAV
131 GCDPDLFWSKIPVLMEEKLFAFDYTGYDASLSPAWFEALKMVLEKIGFGDRVDYIDYL
132 NHSHHLYKNKTYCVKGGMPSGCSGTSIFNSMINNLIIRTLLLKTYKGIDLDHLKMIAY
133 GDDVIASYPHEVDASLLAQSGKDYGLTMTPADKSATFETVTWENVTFLKRFFRADEKY
134 PFLIHPVMPMKEIHESIRWTKDPRNTQDHVRSLCLLAWHNGEEEYNKFLAKIRSVPIG
135 RALLLPEYSTLYRRWLDSF"
136 mat_peptide 746..949
137 /locus_tag="PVgp1"
138 /product="coat protein VP4"
139 /protein_id="NP_740468.1"
140 /db_xref="GI:25121840"
141 mat_peptide 950..1765
142 /locus_tag="PVgp1"
143 /product="coat protein VP2"
144 /protein_id="NP_740469.1"
145 /db_xref="GI:25121841"
146 mat_peptide 1766..2479
147 /locus_tag="PVgp1"
148 /product="coat protein VP3"
149 /protein_id="NP_740470.1"
150 /db_xref="GI:25121842"
151 mat_peptide 2480..3385
152 /locus_tag="PVgp1"
153 /product="coat protein VP1"
154 /protein_id="NP_740471.1"
155 /db_xref="GI:25121843"
156 mat_peptide 3386..3832
157 /locus_tag="PVgp1"
158 /product="Picornain 2A"
159 /note="Small chymotrypsin-like cysteine proteinase"
160 /protein_id="NP_740477.1"
161 /db_xref="GI:25121849"
162 mat_peptide 3833..4123
163 /locus_tag="PVgp1"
164 /product="protein 2B"
165 /protein_id="NP_740472.1"
166 /db_xref="GI:25121844"
167 mat_peptide 4124..5110
168 /locus_tag="PVgp1"
169 /product="protein 2C (NTPase)"
170 /note="Involved in initiation and elongation of RNA
171 synthesis, RNA encapsidation, virus uncoating and
172 guanidine resistance (Asn179-Gly mutation). Putative
173 helicase III."
174 /protein_id="NP_740473.1"
175 /db_xref="GI:25121845"
176 mat_peptide 5111..5371
177 /locus_tag="PVgp1"
178 /product="protein 3A"
179 /protein_id="NP_740474.1"
180 /db_xref="GI:25121846"
181 mat_peptide 5372..5437
182 /locus_tag="PVgp1"
183 /product="genome linked protein VPg"
184 /protein_id="NP_740475.1"
185 /db_xref="GI:25121847"
186 mat_peptide 5438..5986
187 /locus_tag="PVgp1"
188 /product="Picornain 3C"
189 /note="Chymotrypsin-like cystein proteinase 3C"
190 /protein_id="NP_740476.2"
191 /db_xref="GI:62871476"
192 mat_peptide 5987..7369
193 /locus_tag="PVgp1"
194 /product="RNA-directed RNA-polymerase 3D"
195 /protein_id="NP_740478.2"
196 /db_xref="GI:62871477"
197 conflict 1467..1468
198 /locus_tag="PVgp1"
199 /note="GG is G in [3]"
200 /citation=[4]
201 conflict 1529..1530
202 /locus_tag="PVgp1"
203 /note="CC is C in [3]"
204 /citation=[4]
205 conflict 1534..1535
206 /locus_tag="PVgp1"
207 /note="CC is C in [3]"
208 /citation=[4]
209 conflict 1547
210 /locus_tag="PVgp1"
211 /note="C is U in [3]"
212 /citation=[4]
213 conflict 1579
214 /locus_tag="PVgp1"
215 /note="C is A in [3]"
216 /citation=[4]
217 conflict 1601
218 /locus_tag="PVgp1"
219 /note="A is C in [3]"
220 /citation=[4]
221 conflict 1668
222 /locus_tag="PVgp1"
223 /note="C is U in [3]"
224 /citation=[4]
225 conflict 2001
226 /locus_tag="PVgp1"
227 /note="A is C in [3]"
228 /citation=[4]
229 conflict 2004..2006
230 /locus_tag="PVgp1"
231 /note="AUC is CCU in [3]"
232 /citation=[4]
233 conflict 2035
234 /locus_tag="PVgp1"
235 /note="U is C in [3]"
236 /citation=[4]
237 conflict 2133
238 /locus_tag="PVgp1"
239 /note="U is C in [3]"
240 /citation=[4]
241 conflict 2286
242 /locus_tag="PVgp1"
243 /note="C is G in [3]"
244 /citation=[4]
245 conflict 2983
246 /locus_tag="PVgp1"
247 /note="G is A in [3]"
248 /citation=[4]
249 conflict 3043
250 /locus_tag="PVgp1"
251 /note="A is G in [3]"
252 /citation=[4]
253 conflict 3303..3304
254 /locus_tag="PVgp1"
255 /note="GG is G in [3]"
256 /citation=[4]
257 conflict 3308
258 /locus_tag="PVgp1"
259 /note="G is GC in [3]"
260 /citation=[4]
261 conflict 3657
262 /locus_tag="PVgp1"
263 /note="C is U in [3]"
264 /citation=[4]
265 conflict 3696
266 /locus_tag="PVgp1"
267 /note="C is A in [3]"
268 /citation=[4]
269 conflict 3766
270 /locus_tag="PVgp1"
271 /note="C is A in [3]"
272 /citation=[4]
273 conflict 4158
274 /locus_tag="PVgp1"
275 /note="C is CC in [3]"
276 /citation=[4]
277 conflict 4163..4164
278 /locus_tag="PVgp1"
279 /note="GC is G in [3]"
280 /citation=[4]
281 conflict 4174
282 /locus_tag="PVgp1"
283 /note="A is C in [3]"
284 /citation=[4]
285 conflict 5113
286 /locus_tag="PVgp1"
287 /note="A is C in [3]"
288 /citation=[4]
289 conflict 5598
290 /locus_tag="PVgp1"
291 /note="U is C in [3]"
292 /citation=[4]
293 conflict 5619..5623
294 /locus_tag="PVgp1"
295 /note="CGCUC is UGUUU in [3]"
296 /citation=[4]
297 conflict 5645
298 /locus_tag="PVgp1"
299 /note="C is U in [3]"
300 /citation=[4]
301 conflict 5786
302 /locus_tag="PVgp1"
303 /note="G is C in [3]"
304 /citation=[4]
305 conflict 5903..5905
306 /locus_tag="PVgp1"
307 /note="AAA is AA in [3]"
308 /citation=[4]
309 conflict 5927..5931
310 /locus_tag="PVgp1"
311 /note="GGGAA is GGA in [3]"
312 /citation=[4]
313 conflict 5970..5971
314 /locus_tag="PVgp1"
315 /note="AC is UA in [3]"
316 /citation=[4]
317 conflict 5997
318 /locus_tag="PVgp1"
319 /note="A is C in [3]"
320 /citation=[4]
321 conflict 6019
322 /locus_tag="PVgp1"
323 /note="A is C in [3]"
324 /citation=[4]
325 conflict 6021
326 /locus_tag="PVgp1"
327 /note="U is C in [3]"
328 /citation=[4]
329 conflict 6261
330 /locus_tag="PVgp1"
331 /note="C is U in [3]"
332 /citation=[4]
333 conflict 6845..6847
334 /locus_tag="PVgp1"
335 /note="CCA is CA in [2]"
336 /citation=[5]
337 conflict 6978..6979
338 /locus_tag="PVgp1"
339 /note="UU is UUU in [2]"
340 /citation=[5]
341 conflict 7258
342 /locus_tag="PVgp1"
343 /note="U is UU in [2]"
344 /citation=[5]
345 conflict 7410
346 /note="U is C in [3] and [2]"
347 /citation=[4]
348 /citation=[5]
349 conflict 7440
350 /note="G is GG in [3] and [2]"
351 /citation=[4]
352 /citation=[5]
353 ORIGIN
354 1 ttaaaacagc tctggggttg tacccacccc agaggcccac gtggcggcta gtactccggt
355 61 attgcggtac ccttgtacgc ctgttttata ctcccttccc gtaacttaga cgcacaaaac
356 121 caagttcaat agaagggggt acaaaccagt accaccacga acaagcactt ctgtttcccc
357 181 ggtgatgtcg tatagactgc ttgcgtggtt gaaagcgacg gatccgttat ccgcttatgt
358 241 acttcgagaa gcccagtacc acctcggaat cttcgatgcg ttgcgctcag cactcaaccc
359 301 cagagtgtag cttaggctga tgagtctgga catccctcac cggtgacggt ggtccaggct
360 361 gcgttggcgg cctacctatg gctaacgcca tgggacgcta gttgtgaaca aggtgtgaag
361 421 agcctattga gctacataag aatcctccgg cccctgaatg cggctaatcc caacctcgga
362 481 gcaggtggtc acaaaccagt gattggcctg tcgtaacgcg caagtccgtg gcggaaccga
363 541 ctactttggg tgtccgtgtt tccttttatt ttattgtggc tgcttatggt gacaatcaca
364 601 gattgttatc ataaagcgaa ttggattggc catccggtga aagtgagact cattatctat
365 661 ctgtttgctg gatccgctcc attgagtgtg tttactctaa gtacaatttc aacagttatt
366 721 tcaatcagac aattgtatca taatgggtgc tcaggtttca tcacagaaag tgggcgcaca
367 781 tgaaaactca aatagagcgt atggtggttc taccattaat tacaccacca ttaattatta
368 841 tagagattca gctagtaacg cggcttcgaa acaggacttc tctcaagacc cttccaagtt
369 901 caccgagccc atcaaggatg tcctgataaa aacagcccca atgctaaact cgccaaacat
370 961 agaggcttgc gggtatagcg atagagtact gcaattaaca ctgggaaact ccactataac
371 1021 cacacaggag gcggctaatt cagtagtcgc ttatgggcgt tggcctgaat atctgaggga
372 1081 cagcgaagcc aatccagtgg accagccgac agaaccagac gtcgctgcat gcaggtttta
373 1141 tacgctagac accgtgtctt ggacgaaaga gtcgcgaggg tggtggtgga agttgcctga
374 1201 tgcactgagg gacatgggac tctttgggca aaatatgtac taccactacc taggtaggtc
375 1261 cgggtacacc gtgcatgtac agtgtaacgc ctccaaattc caccaggggg cactaggggt
376 1321 attcgccgta ccagagatgt gtctggccgg ggatagcaac accactacca tgcacaccag
377 1381 ctatcaaaat gccaatcctg gcgagaaagg aggcactttc acgggtacgt tcactcctga
378 1441 caacaaccag acatcacctg cccgcaggtt ctgcccggtg gattacctcc ttggaaatgg
379 1501 cacgttgttg gggaatgcct ttgtgttccc gcaccagata ataaacctac ggaccaacaa
380 1561 ctgtgctaca ctggtactcc cttacgtgaa ctccctctcg atagatagta tggtaaagca
381 1621 caataattgg ggaattgcaa tattaccatt ggccccatta aattttgcta gtgagtcctc
382 1681 cccagagatt ccaatcacct tgaccatagc ccctatgtgc tgtgagttca atggattaag
383 1741 aaacatcacc ctgccacgct tacagggcct gccggtcatg aacacccctg gtagcaatca
384 1801 atatcttact gcagacaact tccagtcacc gtgtgcgctg cctgaatttg atgtgacccc
385 1861 acctattgac atacccggtg aagtaaagaa catgatggaa ttggcagaaa tcgacaccat
386 1921 gattcccttt gacttaagtg ccacaaaaaa gaacaccatg gaaatgtata gggttcggtt
387 1981 aagtgacaaa ccacatacag acgatcccat actctgcctg tcactctctc cagcttcaga
388 2041 tcctaggttg tcacatacta tgcttggaga aatcctaaat tactacacac actgggcagg
389 2101 atccctgaag ttcacgtttc tgttctgtgg attcatgatg gcaactggca aactgttggt
390 2161 gtcatacgcg cctcctggag ccgacccacc aaagaagcgt aaggaggcga tgttgggaac
391 2221 acatgtgatc tgggacatag gactgcagtc ctcatgtact atggtagtgc catggattag
392 2281 caacaccacg tatcggcaaa ccatagatga tagtttcacc gaaggcggat acatcagcgt
393 2341 cttctaccaa actagaatag tcgtccctct ttcgacaccc agagagatgg acatccttgg
394 2401 ttttgtgtca gcgtgtaatg acttcagcgt gcgcttgttg cgagatacca cacatataga
395 2461 gcaaaaagcg ctagcacagg ggttaggtca gatgcttgaa agcatgattg acaacacagt
396 2521 ccgtgaaacg gtgggggcgg caacatctag agacgctctc ccaaacactg aagccagtgg
397 2581 accaacacac tccaaggaaa ttccggcact caccgcagtg gaaactgggg ccacaaatcc
398 2641 actagtccct tctgatacag tgcaaaccag acatgttgta caacataggt caaggtcaga
399 2701 gtctagcata gagtctttct tcgcgcgggg tgcatgcgtg accattatga ccgtggataa
400 2761 cccagcttcc accacgaata aggataagct atttgcagtg tggaagatca cttataaaga
401 2821 tactgtccag ttacggagga aattggagtt cttcacctat tctagatttg atatggaact
402 2881 tacctttgtg gttactgcaa atttcactga gactaacaat gggcatgcct taaatcaagt
403 2941 gtaccaaatt atgtacgtac caccaggcgc tccagtgccc gagaaatggg acgactacac
404 3001 atggcaaacc tcatcaaatc catcaatctt ttacacctac ggaacagctc cagcccggat
405 3061 ctcggtaccg tatgttggta tttcgaacgc ctattcacac ttttacgacg gtttttccaa
406 3121 agtaccactg aaggaccagt cggcagcact aggtgactcc ctttatggtg cagcatctct
407 3181 aaatgacttc ggtattttgg ctgttagagt agtcaatgat cacaacccga ccaaggtcac
408 3241 ctccaaaatc agagtgtatc taaaacccaa acacatcaga gtctggtgcc cgcgtccacc
409 3301 gagggcagtg gcgtactacg gccctggagt ggattacaag gatggtacgc ttacacccct
410 3361 ctccaccaag gatctgacca catatggatt cggacaccaa aacaaagcgg tgtacactgc
411 3421 aggttacaaa atttgcaact accacttggc cactcaggat gatttgcaaa acgcagtgaa
412 3481 cgtcatgtgg agtagagacc tcttagtcac agaatcaaga gcccagggca ccgattcaat
413 3541 cgcaaggtgc aattgcaacg caggggtgta ctactgcgag tctagaagga aatactaccc
414 3601 agtatccttc gttggcccaa cgttccagta catggaggct aataactatt acccagctag
415 3661 gtaccagtcc catatgctca ttggccatgg attcgcatct ccaggggatt gtggtggcat
416 3721 actcagatgt caccacgggg tgatagggat cattactgct ggtggcgaag ggttggttgc
417 3781 attttcagac attagagact tgtatgccta cgaagaagaa gccatggaac aaggcatcac
418 3841 caattacata gagtcacttg gggccgcatt tggaagtgga tttactcagc agattagcga
419 3901 caaaataaca gagttgacca atatggtgac cagtaccatc actgaaaagc tacttaagaa
420 3961 cttgatcaag atcatatcct cactagttat tataactagg aactatgaag acaccacaac
421 4021 agtgctcgct accctggccc ttcttgggtg tgatgcttca ccatggcagt ggcttagaaa
422 4081 gaaagcatgc gatgttctgg agatacctta tgtcatcaag caaggtgaca gttggttgaa
423 4141 gaagtttact gaagcatgca acgcagctaa gggactggag tgggtgtcaa acaaaatctc
424 4201 aaaattcatt gattggctca aggagaaaat tatcccacaa gctagagata agttggaatt
425 4261 tgtaacaaaa cttagacaac tagaaatgct ggaaaaccaa atctcaacta tacaccaatc
426 4321 atgccctagt caggaacacc aggaaattct attcaataat gtcagatggt tatccatcca
427 4381 gtctaagagg tttgcccctc tttacgcagt ggaagccaaa agaatacaga aactagagca
428 4441 tactattaac aactacatac agttcaagag caaacaccgt attgaaccag tatgtttgct
429 4501 agtacatggc agccccggaa caggtaaatc tgtagcaacc aacctgattg ctagagccat
430 4561 agctgaaaga gaaaacacgt ccacgtactc gctacccccg gatccatcac acttcgacgg
431 4621 atacaaacaa cagggagtgg tgattatgga cgacctgaat caaaacccag atggtgcgga
432 4681 catgaagctg ttctgtcaga tggtatcaac agtggagttt ataccaccca tggcatccct
433 4741 ggaggagaaa ggaatcctgt ttacttcaaa ttacgttcta gcatccacaa actcaagcag
434 4801 aatttccccc cccactgtgg cacacagtga tgcattagcc aggcgctttg cgttcgacat
435 4861 ggacattcag gtcatgaatg agtattctag agatgggaaa ttgaacatgg ccatggctac
436 4921 tgaaatgtgt aagaactgtc accaaccagc aaactttaag agatgctgtc ctttagtgtg
437 4981 tggtaaggca attcaattaa tggacaaatc ttccagagtt agatacagta ttgaccagat
438 5041 cactacaatg attatcaatg agagaaacag aagatccaac attggcaatt gtatggaggc
439 5101 tttgtttcaa ggaccactcc agtataaaga cttgaaaatt gacatcaaga cgagtccccc
440 5161 tcctgaatgt atcaatgact tgctccaagc agttgactcc caggaggtga gagattactg
441 5221 tgagaagaag ggttggatag tcaacatcac cagccaggtt caaacagaaa ggaacatcaa
442 5281 cagggcaatg acaattctac aagcggtgac aaccttcgcc gcagtggctg gagttgtcta
443 5341 tgtcatgtat aaactgtttg ctggacacca gggagcatac actggtttac caaacaaaaa
444 5401 acccaacgtg cccaccattc ggacagcaaa ggtacaagga ccagggttcg attacgcagt
445 5461 ggctatggct aaaagaaaca ttgttacagc aactactagc aagggagagt tcactatgtt
446 5521 aggagtccac gacaacgtgg ctattttacc aacccacgct tcacctggtg aaagcattgt
447 5581 gatcgatggc aaagaagtgg agatcttgga tgccaaagcg ctcgaagatc aagcaggaac
448 5641 caatcttgaa atcactataa tcactctaaa gagaaatgaa aagttcagag acattagacc
449 5701 acatatacct actcaaatca ctgagacaaa tgatggagtc ttgatcgtga acactagcaa
450 5761 gtaccccaat atgtatgttc ctgtcggtgc tgtgactgaa cagggatatc taaatctcgg
451 5821 tgggcgccaa actgctcgta ctctaatgta caactttcca accagagcag gacagtgtgg
452 5881 tggagtcatc acatgtactg ggaaagtcat cgggatgcat gttggtggga acggttcaca
453 5941 cgggtttgca gcggccctga agcgatcata cttcactcag agtcaaggtg aaatccagtg
454 6001 gatgagacct tcgaaggaag tgggatatcc aatcataaat gccccgtcca aaaccaagct
455 6061 tgaacccagt gctttccact atgtgtttga aggggtgaag gaaccagcag tcctcactaa
456 6121 aaacgatccc aggcttaaga cagactttga ggaggcaatt ttctccaagt acgtgggtaa
457 6181 caaaattact gaagtggatg agtacatgaa agaggcagta gaccactatg ctggccagct
458 6241 catgtcacta gacatcaaca cagaacaaat gtgcttggag gatgccatgt atggcactga
459 6301 tggtctagaa gcacttgatt tgtccaccag tgctggctac ccttatgtag caatgggaaa
460 6361 gaagaagaga gacatcttga acaaacaaac cagagacact aaggaaatgc aaaaactgct
461 6421 cgacacatat ggaatcaacc tcccactggt gacttatgta aaggatgaac ttagatccaa
462 6481 aacaaaggtt gagcagggga aatccagatt aattgaagct tctagtttga atgactcagt
463 6541 ggcaatgaga atggcttttg ggaacctata tgctgctttt cacaaaaacc caggagtgat
464 6601 aacaggttca gcagtggggt gcgatccaga tttgttttgg agcaaaattc cggtattgat
465 6661 ggaagagaag ctgtttgctt ttgactacac agggtatgat gcatctctca gccctgcttg
466 6721 gttcgaggca ctaaagatgg tgcttgagaa aatcggattc ggagacagag ttgactacat
467 6781 cgactaccta aaccactcac accacctgta caagaataaa acatactgtg tcaagggcgg
468 6841 tatgccatct ggctgctcag gcacttcaat ttttaactca atgattaaca acttgattat
469 6901 caggacactc ttactgaaaa cctacaaggg catagattta gaccacctaa aaatgattgc
470 6961 ctatggtgat gatgtaattg cttcctaccc ccatgaagtt gacgctagtc tcctagccca
471 7021 atcaggaaaa gactatggac taactatgac tccagctgac aaatcagcta catttgaaac
472 7081 agtcacatgg gagaatgtaa cattcttgaa gagattcttc agggcagacg agaaataccc
473 7141 atttcttatt catccagtaa tgccaatgaa ggaaattcat gaatcaatta gatggactaa
474 7201 agatcctagg aacactcagg atcacgttcg ctctctgtgc cttttagctt ggcacaatgg
475 7261 cgaagaagaa tataacaaat tcctagctaa aatcaggagt gtgccaattg gaagagcttt
476 7321 attgctccca gagtactcaa cattgtaccg ccgttggctt gactcatttt agtaacccta
477 7381 cctcagtcga attggattgg gtcatactgt tgtaggggta aatttttctt taattcggag
478 //