1 ---------------------------------------------------------
2 Revision history for BioPerl core modules
3 ---------------------------------------------------------
4 The comprehensive history and ongoing development of BioPerl:
6 http://github.com/bioperl/bioperl-live
8 Some of that history is also highlighted on our wiki:
10 http://www.bioperl.org/wiki/Change_log
11 http://www.bioperl.org/wiki/History_of_BioPerl
13 Bugs and requested features list:
15 https://github.com/bioperl/bioperl-live/issues
17 CPAN releases are branched from 'master'.
18 ---------------------------------------------------------
22 In order to reduce the number of dependencies, we are actively encouraging
23 developers wanting to submit new code with additional dependencies to release
24 code in a separate repository and release it on CPAN. We can help assist in this
25 process and can also place this under the 'bioperl' Github organization (and
26 similarly under the bioperl umbrella account in CPAN), though this is not
29 We will also be moving additonal code to other repositories and will release
30 them separately on CPAN. Modules considered obsolute (relies on a dead web
31 service or utilizes strict dependencies that are also considered obsolete) will
38 * The deobfuscator has been removed.
40 * The script `bp_blast2tree` has been moved to the BioPerl-Run
41 distribution since it's mainly a wrapper to modules in there.
43 * The entire Bio::PopGen namespace, Bio::Tree::AlleleNode
44 module, and scripts bp_composite_LD and bp_heterogeneity_test
45 have been moved into a separate distribution named Bio-PopGen.
47 * All modules related to the NeXML format have been moved into a
48 separate distribution named Bio-NeXMLIO. These are:
56 This also means BioPerl is no longer dependent on Bio-Phylo.
58 * All modules interfacing to ACeDB servers have been moved into a
59 separate distribution named Bio-DB-Ace. These are:
62 * Bio::DB::GFF::Adaptor::ace
63 * Bio::DB::GFF::Adaptor::dbi::mysqlace
64 * Bio::DB::GFF::Adaptor::dbi::oracleace
66 This also means BioPerl is no longer dependent on AcePerl.
68 * The module Bio::Draw::Pictogram has been moved to a separate
69 distribution named Bio-Draw-Pictogram. This also means BioPerl
70 is no longer dependent on SVG.
72 * The module Bio::Tree::Draw::Cladogram has been moved to a
73 separate distribution named Bio-Tree-Draw-Cladogram. This also
74 means BioPerl is no longer dependent on PostScript.
76 * The module Bio::TreeIO::svggraph has been moved to a separate
77 distribution named Bio-TreeIO-svggraph. This also means that
78 BioPerl is no longer dependent on SVG-Graph and Tree-DAG_Node.
80 * The module Bio::SeqIO::excel has been moved to a separate
81 distribution named Bio-SeqIO-excel. This also means that
82 BioPerl is no longer dependent on Spreadsheet-ParseExcel.
84 * The entire Bio::PhyloNetwork namespace has been moved to a
85 separate distribution named Bio-PhyloNetwork. This also means
86 that BioPerl is no longer dependent on Algorithm::Munkres,
87 GraphViz, and Array::Compare.
89 * The entire Bio::Asembly namespace has been moved to a separate
90 distribution named Bio-Assembly. This also means that BioPerl
91 is no longer dependent on Bio-SamTools and Sort-Naturally.
93 * The entire Bio::Structure namespace has been moved to a
94 separate distribution named Bio-Structure.
96 * The entire Bio::SeqEvolution namespace has been moved to a
97 separate distribution named Bio-SeqEvolution.
99 * The Bio::Tools::Gel module has been moved into its own
100 distribution named Bio-Tools-Gel.
102 * The entire Bio::Restriction namespace has been moved to a
103 separate distribution named Bio-Restriction.
110 * #247 - Omit unnecessary parent_id attribute added by GFF3Loader [nathanweeks]
111 * #245 - Code coverage fixes [zmughal,cjfields]
112 * #237 - Fix warning in Bio::DB::IndexedBase [willmclaren,bosborne]
113 * #238 - Use a Travis cron job for network tests [zmughal,cjfields]
114 * #218 - Bio::DB::Flat::BinarySearch should use _fh() instead of fh() as fh() does not take arguments in [thibauthourlier,bosborne]
115 * #227 - Bio::SeqIO Ignores first line of sequence [VAR121,bosborne]
116 * #223 - Use Travis Perl helper script and enable coverage [zmughal,cjfields]
117 * #222 - Fix test RemoteDB/Taxonomy.t: requires networking [zmughal,cjfields]
118 * #216 - Apply carsonhh's patch (Inline::C fixes) [carsonh,bosborne]
119 * #213 - Support FTS5 in Bio::DB::SeqFeature::Store::DBI::SQLite [nathanweeks,bosborne]
120 * #210 - Sorting qualifiers while write embl files [hdevillers,cjfields]
121 * #209 - Fixed bug in _toDsspKey() [jvolkening,hlapp]
125 * PAML-related code from bioperl and bioperl-run are now in a separate distribution on CPAN [carandraug]
131 * Minor release to incorporate fix for CPAN indexing, which
132 prevented proper updates [cjfields]
133 * Fix problem in managing Target attribute for gff3 [Jukes34]
134 * Minor bug fixes related to NCBI HTTPS support [cjfields]
140 * We have migrated to Github Pages. This was actually planned, but the
141 recent OBF server compromise forced our hand.
143 Brian Osborne [bosborne] took this under his wing to move docs and has
144 done a tremendous amount of work formatting the site and working out some
145 of the idiosyncracies with the new Jekyll-based design. Mark Jensen, Paul
146 Cantalupo and Franscison Ossandon also helped. Kudos!!
148 * Similarly, the official issue tracker is now Github Issues. This has
149 been updated in the relevant documentation bits (we hope!)
153 * Previously deprecated modules removed
154 * Bio::Tools::Infernal, Bio::Tools::ERPIN, Bio::Tools::RNAMotif
155 * Bio::DB::SeqHound has been removed due to the service no longer being
157 * Bio::Tools::Analysis::Protein::Mitoprot has been removed for security
158 reasons due to the server no longer having a valid cert
159 * Bio::EUtilities, Bio::Biblio are now separate releases on CPAN
160 * Bio::Coordinate, Bio::SearchIO::blastxml,
161 Bio::SearchIO::Writer::BSMLResultWriter are now separate releases to be
166 * Docker instances of tagged releases are available! [hlapp]
167 * NCBI HTTPS support [mjohnson and others]
168 * Bio::SearchIO::infernal
169 - Issue #131: added CMSEARCH parsing support for Infernal 1.1 [pcantalupo]
170 * Bio::Search::HSP::ModelHSP
171 - Added a 'noncanonical_string' method to retrieve the NC line from CMSEARCH
173 * Bio::Search::Result::INFERNALResult
174 - Added new module to represent features of Infernal reports [pcantalupo]
175 * Bio::DB::Taxonomy SQLite option [cjfields]
176 * WrapperBase quoted option values [majensen]
177 * Various documentation fixes and updates [bosborne]
181 * Fixes in Bio::Root::Build to deal with META.json/yml for CPAN indexing [cjfields]
182 * Bio::SeqFeature::Generic spliced_seq() bug fix [Eric Snyder, via bosborne]
183 * NeXML parser fixes [fjossandon]
184 * Bug fix for Bio::DB::SeqFeature memory adapter [lstein]
185 * RT 103272 : SeqFeature database deletion skipped features with a decimal -
186 Joshua Fortriede (Xenbase)
187 * RT 98374: AlignIO issues with sequence names not correctly parsing - Xiaoyu Zhuo
188 * Issue #70: CONTIG parsing in GenBank output fixed [fjossandon]
189 * Issue #76: Circular genome fixes with Bio::Location::Split [fjossandon]
190 * Issue #80: Fix lack of caching issue with Bio::DB::Taxonomy [fjossandon]
191 * Issue #81: Small updates to make sure possible memory leaks are detected [cjfields]
192 * Issue #84: EMBL format wrapping problem [nyamned]
193 * Issue #90: Missing entries for translation tables 24 and 25 [fjossandon]
194 * Issue #95: Speed up of Bio::DB::Fasta::subseq by using a compiled regex
195 or compiled C code (when Inline::C is installed) [rocky]
196 * Fix various Bio::Tools::Analysis remote server config problems [cjfields]
197 * Added several missing 'Data::Stag' and 'LWP::UserAgent' requirements [fjossandon]
198 * Added a workaround in Bio::DB::Registry to get Username in Windows [fjossandon]
199 * For HMMer report parsing, changed "$hsp->bits" to return 0 instead of undef
200 to be consistent with "$hit->bits" behaviour [fjossandon]
201 * Fixed a bug in HMMer3 parsing, where an homology line ending in CS or RF
202 aminoacids made "next_seq" confused and broke the parser [fjossandon]
203 * Adjusted FTLocationFactory.pm to comply with current GenBank Feature Table
204 Definition, so now "join(complement(C..D),complement(A..B))" is equivalent
205 to "complement(join(A..B,C..D))" [fjossandon]
206 * For the many many many fixes that weren't mentioned - blame the release guy!
210 [Significant changes]
212 * Bug/feature issue tracking has moved to GitHub Issues:
213 https://github.com/bioperl/bioperl-live/issues
214 * DB_File has been demoted from "required" to "recommended",
215 which should make easier for Windows users to install BioPerl
216 if they don't need that module.
220 * Bio::Search::HSP::GenericHSP
221 - Bug #3370, added a "posterior_string" method to retrieve the
222 posterior probability lines (PP) from HMMER3 reports [fjossandon]
223 - Added a "consensus_string" method to retrieve the consensus
224 structure lines (CS|RF) from HMMER2 and HMMER3 reports when available [fjossandon]
225 * Bio::SearchIO::hmmer2
226 - The number of identical and conserved residues are now calculated
227 directly from the homology line [fjossandon]
228 - Now the Query Length and Hit Length are reported when the alignment
229 runs until the end of the sequence/model ('.]' or '[]') [fjossandon]
230 - Implemented the capture of the consensus structure lines [fjossandon]
231 * Bio::SearchIO::hmmer3
232 - The number of identical and conserved residues are now calculated
233 directly from the homology line [fjossandon]
234 - Now the Hit Length is reported when the alignment runs until the end
235 of the sequence/model ('.]' or '[]') [fjossandon]
236 - Implemented the capture of the consensus structure lines [fjossandon]
237 - Implemented the capture of the posterior probability lines [fjossandon]
238 - Completed the development of NHMMER parsing, including alignments [fjossandon]
239 * Bio::SearchIO::SearchResultEventBuilder & Bio::SearchIO::IteratedSearchResultEventBuilder
240 - Feature #2615, moved "_init_parse_params", "max_significance, "signif",
241 "min_score", "min_bits, and "hit_filter" methods from
242 'IteratedSearchResultEventBuilder' to parent 'SearchResultEventBuilder'.
243 This means that the Bio::SearchIO->new() parameters '-signif', '-score',
244 '-bits' and '-hit_filter' will now work with other Bio::SearchIO formats
245 besides Blast, instead of being ignored. Added tests for all moved methods
246 using HMMER outputs and run the full test suite and everything pass [fjossandon]
247 * Bio::SeqIO::MultiFile
248 - Autodetection of file format [fangly]
249 * Bio::Tools::GuessSeqFormat:
250 - Format detection from non-seekable filehandles such as STDIN [fangly]
254 * Fix problems when using Storable as backend for cloning [v1.6.x branch, tsibley]
255 * Fix potential problems with Storable in Bio::DB::SeqFeature::Store [tsibley]
256 * SeqFeature::Lite: Fixed wrong strand when using "+", "-", or "." [nathanweeks]
257 * Abstract: Fixed ActivePerl incapability of removing temporary files
258 because of problems closing tied filehandles [fjossandon]
259 * IndexedBase: For Windows' ActivePerl, several LocalDB tests were failing
260 because ActivePerl were producing a ".index.pag" and ".index.dir"
261 files instead of a single ".index" file (like Strawberry Perl).
262 Now those temporary files are correctly considered and deleted. [fjossandon]
263 * Test files: Added missing module requirements (DB_File and Data::Stag)
264 to several tests files that were failing because those modules were
265 not present. Now those test files are correctly skipped instead. [fjossandon]
266 * Blast: Added support to changes in bl2seq from BLAST+ output, which
267 now uses "Subject=" instead of ">" to start hit lines [yschensandiego]
268 * Phylip: Return undef in "next_aln" at file end to avoid
269 an infinite loop [yschensandiego]
270 * HMMER3: When a hit description is too long, it is truncated in
271 the Scores table. In those cases, the more complete description from
272 the Annotation line (>>) will be used [fjossandon]
273 * GenericHSP: Added '.' to gap symbols in "_pre_gaps" (except for ERPIN),
274 since it is now used by HMMER3 format in alignments [fjossandon]
275 * GenericHit: Changed "frac_aligned_query" and "frac_aligned_hit"
276 to return undef if the query/hit length is unknown (like in some
277 HMMER outputs), to avoid division by 0 crashes. Also "query_length"
278 now is set to 0 if its undefined, to be consistent with hit "length" [fjossandon]
279 * HMMER: fixed many bugs in the parsing of Hmmer2 and Hmmer3 outputs,
280 added support to multi-query reports, reduced code redundancy,
281 and eliminated the automatic removal of hits below "inclusion threshold" [fjossandon]
282 * [3369] - Fixed reported bugs in parse from HMMSEARCH3 reports [fjossandon]
283 * [3446] - Fixed wrong marker position in Bio::Map::Physical [fjossandon]
284 * [3455] - Fixed wrong print of DBLink in Genbank file [bosborne]
285 * Fixed some Bio::Root::Utilities subroutines [fjossandon]
286 * Double-quotes on paths are needed in some places [fjossandon]
287 * [3453] - Allow multiple homologies and products in Entrezgene [fjossandon]
288 * Use "NUL" instead of"/dev/null" when running in Windows [fjossandon]
289 * Updated all files from Bio-Root, Bio-Coordinate and Bio-SearchIO-blastxml
290 with the latest changes made in their own repositories [fjossandon]
291 * General synching of files with the master branch [fjossandon]
292 * Fixed tests failing in Windows because of using Linux commands [fjossandon]
293 * Closed many open filehandles that prevented temporary files deletion [fjossandon]
294 * Fixed broken MeSH parser [fjossandon]
295 * Fixed missing detection of format in SeqIO when given a -string [fangly]
299 * Major Windows support updates! [fjossandon]
300 * MAKER update to allow for stricter standard codon table [cjfields]
301 * Better support for circular sequences [fjossandon]
302 * Fixes for some complex location types [fjossandon]
303 * Address CONTIG bug in GenBank format, bug #3448 [cjfields]
304 * Fix bug #2978 related to BLAST report type [fjossandon]
305 * Deobfuscator fixes [DaveMessina]
309 * Address CPAN test failures [cjfields]
310 * Add BIOPROJECT support for Genbank files [hyphaltip]
311 * Better regex support for HMMER3 output [bosborne]
315 * Minor update to address CPAN test failures
319 * Remove Bio::Biblio and related files [carandraug]
320 - this cause version clashes with an independently-released
321 version of Bio::Biblio
327 * Hash randomization fixes for perl 5.18.x
328 - Note: at least one module (Bio::Map::Physical) still has a failing test;
329 this is documented in bug #3446 and has been TODO'd; we will be pulling
330 Bio::Map and similar modules out of core into separate distributions in the
331 1.7.x release series [cjfields]
335 * Bio::Seq::SimulatedRead
336 - New module to represent reads taken from other sequences [fangly]
338 - Support of Clone::Fast as a faster cloning alternative [fangly]
340 - Moved the format() and variant() methods from Bio::*IO modules to
341 Bio::Root::IO [fangly]
342 - Can now use format() to get the type of IO format in use [fangly]
344 - New regexp() method to create regular expressions from IUPAC sequences
346 * Bio::SeqFeature::Primer and Bio::Seq::PrimedSeq:
347 - Code refresh [fangly]
349 - Added support for the Greengenes and Silva taxonomies [fangly]
350 * Bio::Tree::TreeFunctionsI
351 - get_lineage_string() represents a lineage as a string [fangly]
352 - add_trait() returns instead of reporting an error when the column
353 number is exceeded in add_trait() [fangly]
354 - Option to support tree leaves without trait [fangly]
355 - Allow ID of 0 in trait files [fangly]
356 * Bio::DB::Taxonomy::list
357 - Misc optimizations [fangly]
358 - Option -names of get_taxon() to help with ambiguous taxa [fangly]
359 * Bio::DB::Taxonomy::*
360 - get_num_taxa() returns the number of taxa in the database [fangly]
361 * Bio::DB::Fasta and Bio::DB::Qual
362 - support indexing an arbitrary list of files [fangly]
363 - user can supply an arbitrary index file name [fangly]
364 - new option to remove index file at the end [fangly]
366 - now handles IUPAC degenerate residues [fangly]
367 * Bio::PrimarySeq and Bio::PrimarySeqI
368 - speed improvements for large sequences [Ben Woodcroft, fangly]
370 - tightened and optimized quality string validation [fangly]
372 - new method and option 'block', to create FASTA output with space
373 intervaled blocks (similar to genbank or EMBL) has been implemented.
374 - package variables $WIDTH and $DEFAULT_SEQ_ID_TYPE have been removed
375 in favour of the methods 'width' and 'preferred_id_type` respectively.
377 - moved from bioperl-live into the separate distribution Bio-FeatureIO
378 * Bio::SeqFeature::Annotated
379 - moved from bioperl-live into the separate distribution Bio-FeatureIO
380 * Bio::Cluster::SequenceFamily
381 - improved performance when using get_members with overlapping multiple
383 * Bio::SearchIO::hmmer3
384 - now supports nhmmer [bosborne]
388 * [3302] Fixes bug in Bio::SearchIO::hmmer2.pm to correctly parse
389 multi-query hmmer output [Francisco J. Ossandon, Paul Cantalupo]
390 * [3421] Fixes bug in Bio::SearchIO::hmmer2.pm to correctly parse an HSP
391 with a line full of dashes [Francisco J. Ossandon, Paul Cantalupo]
392 * [3298] Fix bug in Bio::SearchIO::blast.pm where algorithm version
393 information was lost in a multi-result blast file [Paul Cantalupo]
394 * [3343] Fix bug in Bio::SearchIO::blasttable.pm to correctly calculate
395 total gaps [Paul Cantalupo]
396 * [3375] Fix DBLINK parsing bug in Bio::SeqIO::genbank.pm [Paul Cantalupo]
397 * [3376] Fix bug in Bio::SearchIO::hmmer2.pm to correctly handle case
398 when end of domain indicator is split across lines [Paul Cantalupo]
399 * [3240] Bio::AlignIO::stockholm now parses simple sequences [Bernd Web,
401 * [3237] Bio::DB::Fasta now allows blank lines between sequences, catches
402 instances where blank lines are within sequences [cjfields]
403 * Bio::DB::Fasta reports correct alphabet for files with multiple sequence
405 * Bio::DB::Fasta rev-comps sequences other than DNA properly [fangly]
406 * [3238] Fixes for Bio::DB::SeqFeature::Store::DBI::Pg [Thomas Burkhard,
408 * Various fixes for Stockholm file indexing and processing [bosborne]
409 * Fix edge case in FASTQ parsing where sequence of length 1 and qual of 0
410 breaks parsing [cjfields]
411 * Fix case where Bio::Seq::Meta* objects with no meta information could not
412 be reverse-complemented [fangly]
413 * Fix bug for fields without aliases in Bio::DB::Query::HIVQuery [fangly]
414 * Fix Bio::PopGen::IO::phase: sort values lexically instead of numerically
415 when unsure that values will be numerical [fangly]
416 * Fix undef warnings in Bio::SeqIO::embl [fangly]
417 * Fix undef warnings in Bio::DB::Fasta and Bio::DB::Qual [fangly]
418 * Fix Bio::Tools::IUPAC should accept any sequence object [fangly]
419 * Fix for 'Inappropriate ioctl' in Bio::DB::Store::berkeleydb3 [Olivier
421 * Bio::SeqFeature::Generic SeqfeatureI compliance: methods primary_tag,
422 source_tag and display_name must return a string, not undef [fangly]
423 * Bio::SimpleAlign and Bio::Seq compliance with Bio::FeatureHolderI
424 add_SeqFeature takes a single argument [fangly]
425 * Use cross-platform filenames and temporary directory in
426 Bio::DB::Taxonomy::flatfile [fangly]
427 * Fix bug in Bio::DB::Taxonomy::list where taxa with no ancestors were not
428 properly identified as existing taxa in the database [fangly]
429 * Fix issue where a Bio::DB::Taxonomy::list object could not be created
430 without also passing a lineage to store [fangly]
431 * Prevent passing a directory to the gi2taxid option (-g) of
432 bp_classify_hits_kingdom.pl and remove an 'earlier declaration' warning
434 * Fixed bp_genbank2gff3.pl crash when missing source feature date [fangly]
435 * Bio::PrimarySeq constructor -direct works for -seq or -ref_to_seq [fangly]
436 * Bio::Cluster::SequenceFamily - checks if the sequence has a Bio::Species
437 object before trying to access, and no longer returns repeated sequences.
444 * Use of AcePerl is deprecated; Ace.pm isn't actively maintained, and
445 modules using Ace will also be deprecated [lds, cjfields]
446 * Minor bug fix release
447 * Bio::SeqIO::gbxml tests require XML::SAX [hartzell]
448 * Address Build.PL issues when DBI is not present [hartzell]
449 * Skip gbxml.t and Interpro tests when modules not installed [cjfields]
450 * Remove deprecated code for perl 5.14.0 compat [cjfields]
451 * Due to schema changes and lack of support for older versions, support
452 for NeXML 0.9 is only (very) partially implemented.
453 See: https://redmine.open-bio.org/issues/3207
457 * [3205] - small fix to Bio::Perl blast_sequence() to make compliant with
458 docs [genehack, cjfields]
459 * $VERSION for CPAN/cpanm-based installs was broken; force setting of
460 module version from dist_version (probably not the best way to do this,
461 but it seems to work) [rbuels, cjfields]
464 1.6.900 April 14, 201
468 * This will probably be the last release to add significant features to
469 core modules; subsequent releases will be for bug fixes alone.
470 We are planning on a restructuring of core for summer 2011, potentially
471 as part of the Google Summer of Code. This may become BioPerl 2.0.
472 * Version bump represents 'just prior to v 1.7'. We may have point
473 releases to deal with bugs, with increments of 1.6.901, 1.6.902, etc.
474 This code essentially is what is on the github master branch.
478 * Core code updated for perl 5.12.x [cjfields, Charle Tilford]
480 - major overhaul of Bio::Tree code by Greg Jordan, fixes several bugs
481 - removal of Scalar::Util::weaken code, which was causing odd headaches
482 with premature GC, memory leaks with perl 5.10.0, etc [cjfields]
483 * Bio::DB::SeqFeature bug fixes for GBrowse2 compatibility [lds, scottcain,
485 * Bio::SeqIO::msout, Bio::SeqIO::mbsout - parsers for ms and mbs
488 - bug 2515 - new contribution [Ryan Golhar, jhannah]
490 - support for reading Maq, Sam and Bowtie files [maj]
491 - support for reading 454 GS Assembler (Newbler) ACE files [fangly]
492 - bug 2483: support for writing ACE files [Joshua Udall, fangly]
493 - bug 2599: support DBLINK annotation in GenBank files [cjfields]
494 - bug 2726: reading/writing granularity: whole scaffold or one contig
495 at a time [Joshua Udall, fangly]
497 - Added parsing of xrefs to OBO files, which are stored as secondary
498 dbxrefs of the cvterm [Naama Menda]
499 - General Interpro-related code refactors [dukeleto, rbuels, cjfields]
500 * PAML code updated to work with PAML 4.4d [DaveMessina]
504 * [3198] - sort tabular BLAST hits by score [DaveMessina]
505 * [3196] - fix invalid metadata produced by latest Module::Build [cjfields]
506 * [3190] - RemoteBlast GAPCOSTS regex fix [Ali Walsh, cjfields]
507 * [3185] - Bio::Tools::SeqStats->get_mol_wt now gives correct MW
509 * [3178] - fix tr/// issue in Bio::Range [Andrew Conley, cjfields]
510 * [3172] - Bio::DB::Fasta - catch possibly bad FASTA files [cjfields]
511 * [3164] - TreeFunctionsI syntax bug [gjuggler]
512 * [3163] - AssemblyIO speedup [fangly]
513 * [3160] - Bio::SearchIO::Writer::TextResultWriter output [Paul Cantalupo,
515 * [3159] - add SwissPfam support to bp_index.PLS [hyphaltip]
516 * [3158] - fix EMBL file mis-parsing [cjfields]
517 * [3157] - Bio::Restriction::Analysis 'sizes' method fixed [Marc Perry,
519 * [3153] - fix SeqIO::swiss TagTree issues [Charles Tilford, cjfields]
520 * [3148] - URL change for UniProt [cjfields]
521 * [3145] - AXT off-by-1 error [Aaron Goodman, cjfields]
522 * [3136] - HMMer3 parser fixes [kblin]
523 * [3126] - catch description [Toshihiko Akiba]
524 * [3122] - Catch instances where non-seekable filehandles were being
525 seek'd w/o checking for status [Stefan Kirov, Roy Chaudhuri]
526 * [3121] - Bio::OntologyIO cannot parse the full InterPro XML file
527 [dukeleto, rbuels, cjfields]
528 * [3120] - bp_seqfeature_gff3.pl round-trip fixes [genehack, David Breimann,
530 * [3116,3117] - perl 5.12.x warnings fixed [cjfields, Charles Tilford]
531 * [3110] - Better 'namespace' support for bp_seqfeature_load.PLS [dbolser,
533 * [3107] - BLAST alignment column_from_residue_number() [cjfields]
534 * [3104] - Bio::Species single node hierarchies [Charles Tilford, cjfields]
535 * [3092, 3090] - parsing of BLAST HSP stats [Razi Khaja, cjfields]
536 * [3089] - HSPTableWriter missing methods [Robson de Souza, cjfields]
537 * [3086] - EMBL misparsing long tags [kblin, cjfields]
538 * [3085] - CommandExts and array of files [maj, hyphaltip]
539 * [3077] - Bio::SimpleAlign slice() now correctly computes seq coordinates
540 for alignment slices [Ha X. Dang, cjfields]
541 * [3076] - XMFA alignment strand wrong [Ha X., cjfields]
542 * [3073] - fix parsing of GenBank files from RDP [cjfields]
543 * [3068] - FASTQ parse failure with trailing 0 [cjfields]
544 * [3064] - All-gap midline BLAST report issues [cjfields]
545 * [3063] - BLASt report RID [Razi Khaja, cjfields]
546 * [3058] - SearchIO::fasta parsing [DaveMessina, cjfields]
547 * [3053] - LOCUS line formatting [M. Wayne, cjfields]
548 * [3039] - correct Newick output root node branch length [gjuggler,
550 * [3038] - SELEX alignment error [Bernd, cjfields]
551 * [3033] - PrimarySeq ID setting [Bernd, maj]
552 * [3032] - Fgenesh errors [Wes Barris, hyphaltip]
553 * [3034] - AlignIO::clustal output [Bernd, DaveMessina]
554 * [3031] - Parse algorithm ref for BLAST [Razi Khaja, cjfields]
555 * [3028] - Bio::TreeIO::nexus and FigTree compat [Kevin Balbi, cjfields]
556 * [3025] - Bio::SeqIO::embl infinite loop [Adam Sjøgren, cjfields]
557 * [3040, 3023, 2974, 2921, 2753, 2636, 2482] - PAML parser fixed, works with
558 PAML 4.4d [DaveMessina]
559 * [3015, 3022] - Bio::Restriction withrefm regexp [Emmanuel Quevillon,
561 * [3020] - GFF3Loader alias attribute [Nathan Weeks, cjfields]
562 * [3018, 3019, 3021] - gmap_f9 parsing [Kiran Mukhyala, cjfields]
563 * [3017] - using threads with Bio::DB::GenBank [cjfields]
564 * [3012] - Bio::Root::HTTPget fixes [maj, cjfields]
565 * [3011] - namespace support for SF::Store::DBI::Pg [Adam Witney, cjfields]
566 * [3002] - Bio::DB::EUtilities NCBI policy updates [cjfields]
567 * [3001] - seq identifier '0' dropped with FASTA [Michael Kuhn, maj]
568 * [2984] - let LocatableSeq decide on length of phylip aln [Adam Witney,
570 * [2983] - fix score/percent ID mixup [Alexie Papanicolaou]
571 * [2977] - TreeIO issues [DaveMessina]
572 * [2959] - Bio::SeqUtils->revcom_with_features [Roy Chaudhuri, maj]
573 * [2944] - Bio::Tools::GFF score [cjfields]
574 * [2942] - correct MapTiling output [maj]
575 * [2939] - PDB residue insertion codes [John May, maj]
576 * [2930] - PrimarySeqI term symbol [Adam Sjøgren, maj]
577 * [2928] - GuessSeqFormat raw [maj]
578 * [2926] - Bio:Tools::TandemRepeatsFinder seq_id [takadonet, cjfields]
579 * [2922] - open() directive issue [cjfields]
580 * [2915] - GenBank parser infinite loop [Francisco Ossandon, cjfields]
581 * [2901] - DNAStatistics div by zero error [Janet Young, cjfields]
582 * [2899] - SeqFeature::Store host issues [lstein, dbolser]
583 * [2897] - Add a "mask_below_threshold" method to Seq::Quality [dbolser,
585 * [2881] - .scf files don't' roundtrip [Adam Sjøgren, cjfields]
586 * [2876] - CDD search with RemoteBlast [Malcolm Cook]
587 * [2863] - Root::IO::_initialize_io causes crash [rbuels, maj, DaveMessina]
588 * [2845] - Bio::Seq::Quality gives seq with no ID [Tristan Lefebure, cjfields]
589 * [2843] - FeatureIO BED to GFF fails w/ no phase [cassjm cjfields]
590 * [2773] - Bio::Tree::Node premature GC [Morgan Price, cjfields]
591 * [2764] - add ID Tracker helper for SwissProt [heikki, cjfields]
592 * [2758] - Bio::AssemblyIO ace problems [fangly]
593 * [2744] - Bio::LocatableSeq::end [Bernd, cjfields]
594 * [2726] - ace file IO [Josh, fangly]
595 * [2700] - Refactor Build.PL [cjfields]
596 * [2673] - addition of simple Root-based clone() method [cjfields]
597 * [2648] - Bio::Assembly::Scaffold->get_all_seq_ids [dbolser, fangly]
598 * [2599] - support for DBLINK annotation in GenBank files [cjfields]
599 * [2594] - Bio::Species memory leak [cjfields]
600 * [2515] - GenBank XML parser [jhannah]
601 * [2499] - Method "pi" in package Bio::PopGen::Statistics [hyphaltip]
602 * [2483] - Bio::Assembly::IO::ace write_assembly implemented [fangly]
603 * [2350] - ID consistency btwn Bio::SeqI, Bio::Align::AlignI [fangly,
605 * [1572] - no docs Bio::Location::Simple/Atomic::trunc [hyphaltip]
609 * Bio::Expression modules - these were originally designed to go with the
610 bioperl-microarray suite of tools, however they have never been completed
611 and so have been removed from the distribution. The original code has
612 been moved into the inactive bioperl-microarray suite. [cjfields]
616 * Repository moved from Subversion (SVN) to
617 http://github.com/bioperl/bioperl-live [cjfields]
618 * Bug database has moved to Redmine (https://redmine.open-bio.org)
619 * Bio::Micrarray - the tools developed for ReSeq chip analysis by Marian
620 Thieme have been moved to their own distribution (Bio-Microarray).
623 1.6.1 Sept. 29, 2009 (point release)
624 * No change from last alpha except VERSION and doc updates [cjfields]
626 1.6.0_6 Sept. 27, 2009 (sixth 1.6.1 alpha)
627 * Fix for silent OBDA bug related to FASTA validation [cjfields]
629 1.6.0_5 Sept. 27, 2009 (fifth 1.6.1 alpha)
630 * Possible fix for RT 49950 (Strawberry Perl installation) [cjfields]
631 * [RT 50048] - removed redundant VERSION, which was borking CPANPLUS
633 * BioPerl.pod -> BioPerl.pm (Perl Best Practices) [cjfields]
635 1.6.0_4 Sept. 25, 2009 (fourth 1.6.1 alpha)
636 * WinXP test fixes [cjfields, maj]
637 * BioPerl.pod added for descriptive information, fixes CPAN indexing
639 * Minor doc fixes [cjfields]
641 1.6.0_3 Sept. 22, 2009 (third 1.6.1 alpha)
642 * Fix tests failing due to merging issues [cjfields]
643 * More documentation updates for POD parsing [cjfields]
645 1.6.0_2 Sept. 22, 2009 (second 1.6.1 alpha)
647 - fix YAML meta data generation [cjfields]
649 1.6.0_1 Sept. 15, 2009 (first 1.6.1 alpha)
650 * Bio::Align::DNAStatistics
651 - fix divide by zero problem [jason]
653 - bug 2813 - fix faulty logic to detect end-of-stream [cjfields]
654 * Bio::AlignIO::stockholm
655 - bug 2796 - fix faulty logic to detect end-of-stream [cjfields]
656 * Bio::Assembly::Tools::ContigSpectrum
657 - function to score contig spectrum [fangly]
658 * Bio::DB::EUtilities
659 - small updates [cjfields]
661 - berkeleydb database now autoindexes wig files and locks correctly
664 - various small updates for stability; tracking changes to LANL
665 database interface [maj]
666 * Bio::DB::SeqFeature (lots of updates and changes)
667 - add Pg, SQLite, and faster BerkeleyDB implementations [lstein, scain]
668 - bug 2835 - patch [Dan Bolser]
669 - bug RT 44535 - patch FeatureFileLoader [Cathy Gresham]
671 - bug 2764 - idtracker() method [cjfields, courtesy Neil Saunders]
672 * Bio::Factory::FTLocationFactory
673 - mailing list bug fix [cjfields]
675 - performance work on column_from_residue_number [hartzell]
676 * Bio::Matrix::IO::phylip
677 - bug 2800 - patch to fix phylip parsing [Wei Zou]
679 - Google Summer of Code project from Chase Miller - parsers for Nexml
680 file format [maj, chmille4]
682 - Make Individual, Population, Marker objects AnnotatableI [maj]
683 - simplify LD code [jason]
685 - deal with empty intersection [jason]
687 - significant overhaul of Bio::Restriction system: complete support for
688 external and non-palindromic cutters. [maj]
690 - CPANPLUS support, no automatic installation [sendu]
692 - allow IO::String (regression fix) [cjfields]
693 - catch unintentional undef values [cjfields]
694 - throw if non-fh is passed to -fh [maj]
695 * Bio::Root::Root/RootI
696 - small debugging and core fixes [cjfields]
698 - bug RT 48813 - fix for Strawberry Perl bug [kmx]
699 * Bio::Root::Utilities
700 - bug 2737 - better warnings [cjfields]
702 - tiling completely refactored, HOWTO added [maj]
703 NOTE : Bio::Search::Hit::* classes do not use this code directly; we
704 will deprecate usage of the older tiling code in the next BioPerl
706 - small fixes [cjfields]
708 - Infernal 1.0 output now parsed [cjfields]
709 - new parser for gmap -f9 output [hartzell]
710 - bug 2852 - fix infinite loop in some output [cjfields]
711 - blastxml output now passes all TODO tests [cjfields]
712 - bug 2346, 2850 - psl and exonerate parsing fixes [rbuels, jhannah, bvecchi, YAPC hackathon]
713 - RT 44782 - GbrowseGFF writer now catches evalues [Allen Day]
714 - bug 2575 - add two columns of additional output to HSPTableWriter [cjfields]
715 * Bio::Seq::LargePrimarySeq
716 - delete tempdirs [cjfields]
717 - bug fixes [rbuels, jhannah, bvecchi, YAPC hackathon]
719 - extract regions based on quality threshold value [Dan Bolser, heikki]
720 - bug 2847 - resolve threshold issue (rbuels, jhannah, bvecchi)
721 * Bio::SeqFeature::Lite
722 - various Bio::DB::SeqFeature-related fixes [lstein]
723 * Bio::SeqFeature::Tools::TypeMapper
724 - additional terms for GenBank to SO map [scain]
725 * Bio::SeqIO::chadoxml
726 - bug 2785 - patch to get this working for bp_seqconvert [cjfields]
728 - support for CDS records [dave_messina, Sylvia]
730 - complete refactoring to handle all FASTQ variants, perform validation,
731 write output. API now conforms with other Bio* parsers and the rest of
732 Bio::SeqIO (e.g. write_seq() creates fastq output, not fasta output).
734 * Bio::SeqIO::genbank
735 - bug 2784 - fix DBSOURCE issue [Phillip Garland]
736 - bug RT 44536 - support for UniProt/UniProtKB tests [cjfields]
737 * Bio::SeqIO::largefasta
738 - parser returns a Bio::Seq::LargePrimarySeq [jhannah]
740 - add option for 'single' and 'multiple'
742 - bug 2881 - fix scf round-tripping [Adam Søgren]
744 - bug 2766, 2810 - copy over tags from features, doc fixes [David
747 - bug 2793 - patch for add_seq index issue [jhannah, maj]
748 - bug 2801 - throw if args are required [cjfields]
749 - bug 2805 - uniq_seq returns SimpleAlign and hash ref of sequence types
750 [Tristan Lefebure, maj]
751 - bug fixes from YAPC hackathon [rbuels, jhannah, bvecchi]
752 - fix POD and add get_SeqFeatures filter [maj]
753 * Bio::Tools::dpAlign
754 - add support for LocatableSeq [ymc]
755 - to be moved to a separate distribution [cjfields, rbuels]
756 * Bio::Tools::EUtilities
757 - fix for two bugs from mail list [Adam Whitney, cjfields]
758 - add generic ItemContainerI interface for containing same methods
761 - fix up code, add more warnings [cjfields]
762 - to be moved to a separate distribution [cjfields, rbuels]
763 * Bio::Tools::Primer3
764 - bug 2862 - fenceposting issue fixed [maj]
765 * Bio::Tools::Run::RemoteBlast
766 - tests for remote RPS-BLAST [mcook]
767 * Bio::Tools::SeqPattern
768 - bug 2844 - backtranslate method [rbuels, jhannah, bvecchi]
769 * Bio::Tools::tRNAscanSE
770 - use 'gene' and 'exon' for proper SO, ensure ID is unique [jason]
772 - bug 2456 - fix reroot_tree(), added create_node_on_branch() [maj]
773 * Bio::Tree::Statistics
774 - several methods for calculating Fitch-based score, internal trait
775 values, statratio(), sum of leaf distances [heikki]
777 - bug 2869 - add docs indicating edge case where nodes can be
778 prematurely garbage-collected [cjfields]
779 - add as_text() function to create Tree as a string in specified format
781 * Bio::Tree::TreeFunctionsI
782 - bug 2877 - fix bug where bootstrap assigned to the wrong node [Tristan
784 * Bio::TreeIO::newick
785 - fix small semicolon issue [cjfields]
787 - update to bp_seqfeature_load for SQLite [lstein]
788 - hivq.pl - commmand-line interface to Bio::DB::HIV [maj]
789 - fastam9_to_table - fix for MPI output [jason]
790 - gccalc - total stats [jason]
792 - POD cleanup re: FEEDBACK section [maj, cjfields]
793 - cleanup or fix dead links [cjfields]
794 - Use of no_* methods (indicating 'number of something') is deprecated
795 in favor of num_* [cjfields]
796 - lots of new tests for the above bugs and refactors [everyone!]
797 - new template for Komodo text editor [cjfields]
800 * Feature/Annotation rollback
801 - Problematic changes introduced prior to the 1.5 release have been
802 rolled back. These changes led to subtle bugs involving operator
803 overloading and interface methods.
804 - Behavior is very similar to that for BioPerl 1.4, with tag values
805 being stored generically as simple scalars. Results in a modest
808 - Split into a separate distribution on CPAN, primarily so development
809 isn't reliant on a complete BioPerl release.
810 - Bio::Graphics::Pictogram has been renamed to Bio::Draw::Pictogram but
811 is only available via Subversion (via bioperl-live main trunk)
813 - Common test bed for all BioPerl modules
815 - Common Module::Build-based subclass for all BioPerl modules
816 * Bio::DB::EUtilities
817 - Complete refactoring to split up parsing (Bio::Tools::EUtilities),
818 parameter handling (Bio::Tools::EUtilities::EUtilParameters),
819 and user agent request posting and retrieval
820 * Test implementation and reorganization
821 - Tests have been reorganized into groups based on classes or use
823 - Automated test coverage is now online:
824 http://www.bioperl.org/wiki/Test_Coverage
825 - After this release, untested modules will be moved into a
826 separate developer distribution until tests can be derived.
827 Also, new modules to be added are expected to have a test suite
828 and adequate test coverage.
830 1.5.2 Developer release
832 Full details of changes since 1.5.1 are available online at:
833 http://www.bioperl.org/wiki/Change_log
834 The following represents a brief overview of the most important changes.
837 - Overhaul. Brand new system fully allows markers to have multiple
838 positions on multiple maps, and to have relative positions. Should be
842 - This module and all the modules in the Taxonomy directory now
843 deprecated in favour of Bio::Taxon and Bio::Tree::Tree
848 * get_Taxonomy_Node() eventually to be deprecated, renamed get_taxon().
850 * New methods ancestor(), each_Descendent() and _handle_internal_id().
852 * Allows for different database modules to create Bio::Taxon objects
853 with the same internal id when the same taxon is requested from each.
856 * get_Children_Taxids() is deprecated, superceded by each_Descendent().
858 * No longer includes the fake root node 'root'; there are multiple roots
859 now (10239, 12884, 12908, 29384 and 131567). Consistent with entrez.pm
862 * get_node() has new option -full
864 * Caches data retrieved from website
867 - Now a Bio::Taxon. Carries out the species name -> specific name munging
868 that Bio::DB::Taxonomy modules and SeqIO modules used to do, for
869 backward compatability in species() method.
871 o Bio::Search and Bio::SearchIO
872 - Overhaul. The existing system has been sped up via some minor changes
873 (mostly gain-of-function to the API). Bio::PullParserI is introduced
874 as a potential eventual replacment for the existing system, though as
875 yet only a Hmmpfam parser exists written using it.
878 1.5.1 Developer release
880 o Major problem with how Annotations were written out with
881 Bio::Seq is fixed by reverting to old behavior for
882 Bio::Annotation objects.
887 * bug #1871; REFLOOP' parsing loop, I changed the pattern to
888 expect at l east 9 spaces at the beginning of a line to
889 indicate line wrapping.
891 * Treat multi-line SOURCE sections correctly, this defect broke
892 both common_name() and classification()
894 * parse swissprot fields in genpept file
896 * parse WGS genbank records
899 * Changed regexp for ID line. The capturing parentheses are
900 the same, the difference is an optional repeated-not-semi-
901 colon expression following the captured \S+. This means the
902 regexp works when the division looks like /PRO;/ or when the
903 division looks like /ANG ;/ - the latter is from EMBL
906 * fix ID line parsing: the molecule string can have spaces in
907 it. Like: "genomic DNA"
909 - swiss.pm: bugs #1727, #1734
912 * Added parser for entrezgene ASN1 (text format) files.
913 Uses Bio::ASN1::EntrezGene as a low level parser (get it from CPAN)
917 - maf.pm coordinate problem fixed
919 o Bio::Taxonomy and Bio::DB::Taxonomy
921 - Parse NCBI XML now so that nearly all the taxonomy up-and-down
922 can be done via Web without downloading all the sequence.
924 o Bio::Tools::Run::RemoteBlast supports more options and complies
925 to changes to the NCBI interface. It is reccomended that you
926 retrieve the data in XML instead of plain-text BLAST report to
927 insure proper parsing and retrieval of all information as NCBI
928 fully expects to change things in the future.
930 o Bio::Tree and Bio::TreeIO
932 - Fixes so that re-rooting a tree works properly
934 - Writing out nhx format from a newick/nexus file will properly output
935 bootstrap information. The use must move the internal node labels over
937 for my $node ( grep { ! $_->is_Leaf } $tree->get_nodes ) {
938 $node->bootstrap($node->id);
941 - Nexus parsing is much more flexible now, does not care about
944 - Cladogram drawing module in Bio::Tree::Draw
946 - Node height and depth now properly calculated
948 - fix tree pruning algorithm so that node with 1 child gets merged
950 o Graphics tweaks. Glyph::xyplot improved. Many other small-medium sized
951 bugs and improvements were added, see Gbrowse mailing list for most of
954 o Bio::DB::GFF partially supports GFF3. See information about
955 gff3_munge flag in scripts/Bio-DB-GFF/bulk_load_gff.pl.
957 o Better location parsing in Bio::Factory::FTLocationFactory -
958 this is part of the engine for parsing EMBL/GenBank feature table
959 locations. Nested join/order-by/complement are allowed now
961 o Bio::PrimarySeqI->translate now takes named parameters
963 o Bio::Tools::Phylo::PAML - parsing RST (ancestral sequence
964 reconstruction) is now supported. Parsing different models and
965 branch specific parametes are now supported.
967 o Bio::Factory::FTLocationFactory - parse hierarchical locations
970 o Bio::Matrix::DistanceMatrix returns arrayrefs instead of arrays
971 for getter/setter functions
975 - blast bug #1739; match scientific notation in score
976 and possible e+ values
978 - blast.pm reads more WU-BLAST parameters and parameters, match
979 a full database pathname,
981 - Handle NCBI WEB and newer BLAST formats specifically
982 (Query|Sbjct:) match in alignment blocks can now be (Query|Sbjct).
984 - psl off-by-one error fixed
986 - exonerate parsing much improved, CIGAR and VULGAR can be parsed
987 and HSPs can be constructed from them.
989 - HSPs query/hit now have a seqdesc field filled out (this was
990 always available via $hit->description and
991 $result->query_description
993 - hmmer.pm can parse -A0 hmmpfam files
995 - Writer::GbrowseGFF more customizeable.
997 o Bio::Tools::Hmmpfam
998 make e-value default score displayed in gff, rather than raw score
999 allow parse of multiple records
1002 1.5 Developer release
1004 o Bio::Align::DNAStatistics and Bio::Align::ProteinStatistics
1005 provide Jukes-Cantor and Kimura pairwise distance methods,
1008 o Bio::AlignIO support for "po" format of POA, and "maf";
1009 Bio::AlignIO::largemultifasta is a new alternative to
1010 Bio::AlignIO::fasta for temporary file-based manipulation of
1011 particularly large multiple sequence alignments.
1013 o Bio::Assembly::Singlet allows orphan, unassembled sequences to
1014 be treated similarly as an assembled contig.
1016 o Bio::CodonUsage provides new rare_codon() and probable_codons()
1017 methods for identifying particular codons that encode a given
1020 o Bio::Coordinate::Utils provides new from_align() method to build
1021 a Bio::Coordinate pair directly from a
1022 Bio::Align::AlignI-conforming object.
1024 o Bio::DB::Biblio::eutils is a class for querying NCBI's Eutils.
1025 Send a Pubmed, Pubmed Central, Entrez, or other query to NCBI's
1026 web service using standard Pubmed query syntax, and retrieve
1029 o Bio::DB::GFF has various sundry bug fixes.
1031 o Bio::FeatureIO is a new SeqIO-style subsystem for
1032 writing/reading genomic features to/from files. I/O classes
1033 exist for BED, GTF (aka GFF v2.5), and GFF v3. Bio::FeatureIO
1034 classes only read/write Bio::SeqFeature::Annotated objects.
1035 Notably, the GFF v3 class requires features to be typed into the
1038 o Bio::Graph namespace contains new modules for manipulation and
1039 analysis of protein interaction graphs.
1041 o Bio::Graphics has many bug fixes and shiny new glyphs.
1043 o Bio::Index::Hmmer and Bio::Index::Qual provide multiple-file
1044 indexing for HMMER reports and FASTA qual files, respectively.
1046 o Bio::Map::Clone, Bio::Map::Contig, and Bio::Map::FPCMarker are
1047 new objects that can be placed within a Bio::Map::MapI-compliant
1048 genetic/physical map; Bio::Map::Physical provides a new physical
1049 map type; Bio::MapIO::fpc provides finger-printed clone mapping
1052 o Bio::Matrix::PSM provide new support for postion-specific
1053 (scoring) matrices (e.g. profiles, or "possums").
1055 o Bio::Ontology::Ontology and Bio::Ontology::Term objects can now
1056 be instantiated without explicitly using Bio::OntologyIO. This
1057 is possible through changes to Bio::Ontology::OntologyStore to
1058 download ontology files from the web as necessary. Locations of
1059 ontology files are hard-coded into
1060 Bio::Ontology::DocumentRegistry.
1062 o Bio::PopGen includes many new methods and data types for
1063 population genetics analyses.
1065 o New constructor to Bio::Range, unions(). Given a list of
1066 ranges, returns another list of "flattened" ranges --
1067 overlapping ranges are merged into a single range with the
1068 mininum and maximum coordinates of the entire overlapping group.
1070 o Bio::Root::IO now supports -url, in addition to -file and -fh.
1071 The new -url argument allows one to specify the network address
1072 of a file for input. -url currently only works for GET
1073 requests, and thus is read-only.
1075 o Bio::SearchIO::hmmer now returns individual Hit objects for each
1076 domain alignment (thus containing only one HSP); previously
1077 separate alignments would be merged into one hit if the domain
1078 involved in the alignments was the same, but this only worked
1079 when the repeated domain occured without interruption by any
1080 other domain, leading to a confusing mixture of Hit and HSP
1083 o Bio::Search::Result::ResultI-compliant report objects now
1084 implement the "get_statistics" method to access
1085 Bio::Search::StatisticsI objects that encapsulate any
1086 statistical parameters associated with the search (e.g. Karlin's
1087 lambda for BLAST/FASTA).
1089 o Bio::Seq::LargeLocatableSeq combines the functionality already
1090 found in Bio::Seq::LargeSeq and Bio::LocatableSeq.
1092 o Bio::SeqFeature::Annotated is a replacement for
1093 Bio::SeqFeature::Generic. It breaks compliance with the
1094 Bio::SeqFeatureI interface because the author was sick of
1095 dealing with untyped annotation tags. All
1096 Bio::SeqFeature::Annotated annotations are Bio::AnnotationI
1097 compliant, and accessible through Bio::Annotation::Collection.
1099 o Bio::SeqFeature::Primer implements a Tm() method for primer
1100 melting point predictions.
1102 o Bio::SeqIO now supports AGAVE, BSML (via SAX), CHAOS-XML,
1103 InterProScan-XML, TIGR-XML, and NCBI TinySeq formats.
1105 o Bio::Taxonomy::Node now implements the methods necessary for
1106 Bio::Species interoperability.
1108 o Bio::Tools::CodonTable has new reverse_translate_all() and
1109 make_iupac_string() methods.
1111 o Bio::Tools::dpAlign now provides sequence profile alignments.
1113 o Bio::Tools::GFF now parses GFF version 2.5 (a.k.a. GTF).
1115 o Bio::Tools::Fgenesh, Bio::Tools::tRNAscanSE are new report
1118 o Bio::Tools::SiRNA includes two new rulesets (Saigo and Tuschl)
1119 for designing small inhibitory RNA.
1121 o Bio::Tree::DistanceFactory provides NJ and UPGMA tree-building
1122 methods based on a distance matrix.
1124 o Bio::Tree::Statistics provides an assess_bootstrap() method to
1125 calculate bootstrap support values on a guide tree topology,
1126 based on provided bootstrap tree topologies.
1128 o Bio::TreeIO now supports the Pagel (PAG) tree format.
1134 o Improvements to Bio::AlignIO::nexus for parsing TreeBase nexus files
1136 o Bio::Graphics will work with gd1 or gd2
1139 - hmmer.pm Better hmmpfam parsing, fix bug for small number of alignment outputs
1141 - blast.pm Parse multi-line query fields properly
1142 - small speed improvements to blasttable.pm and others
1144 o Bio::DB::Taxonomy has better support for hierarchy traversal so that
1145 Bio::Taxonomy::Node can be as simple as Bio::Species object while still
1146 supporting more complex queries
1149 1.4. Stable major release
1151 Since initial 1.2.0, 3000 separate changes have been made to make this release.
1153 o installable scripts
1155 o global module version from Bio::Root:Version
1158 - major improvements; SVG support
1161 - population genetics
1162 - support several population genetics types of questions.
1163 - Tests for statistical neutrality of mutations
1164 (Fu and Li's D/F, Tajima's D) are in Bio::PopGen::Statistics.
1165 Tests of population structure (Wright's F-statistic: Fst) is in
1166 Bio::PopGen::PopStats. Calculating composite linkage
1167 disequilibrium (LD) is available in Bio::PopGen::Statistics as
1169 - Bio::PopGen::IO for reading in prettybase (SeattleSNPs)
1170 and csv (comma delimited formatted) data.
1172 - a directory for implementing population simulations has
1173 been added Bio::PopGen::Simulation and 2 simulations - a
1174 Coalescent and a simple single-locus multi-allele genetic drift
1175 simulation have been provided. This replaces the code in
1176 Bio::Tree::RandomTree which has been deprecated until proper
1177 methods for generating random phylogenetic trees are
1181 - new restrion analysis modules
1183 o Bio::Tools::Analysis
1184 - web based DNA and Protein analysis framework and several
1188 - per residue annotable sequences
1191 - Bio::Matrix::PSM - Position Scoring Matrix
1192 - Bio::Matrix::IO has been added for generalized parsing of
1193 matrix data. Matrix::IO::scoring and Matrix::IO::phylip are
1194 initial implementations for parsing BLOSUM/PAM and Phylip
1195 Distance matricies respectively. A generic matrix
1196 implementation for general use was added in
1197 Bio::Matrix::Generic.
1204 o Bio::Tools::SiRNA, Bio::SeqFeature::SiRNA
1205 - small inhibitory RNA
1207 o Bio::SeqFeature::Tools
1208 - seqFeature mapping tools
1209 - Bio::SeqFeature::Tools::Unflattener.pm
1210 -- deal with mapping GenBank feature collections into
1211 Chado/GFF3 processable feature sets (with SO term mappings)
1213 o Bio::Tools::dpAlign
1214 - pure perl dynamic programming sequence alignment
1217 o new Bio::SearchIO formats
1218 - axt and psl: UCSC formats.
1219 - blasttable: NCBI -m 8 or -m 9 format from blastall
1221 o new Bio::SeqIO formats
1222 - chado, tab, kegg, tigr, game
1223 - important fixes for old modules
1227 o improved Bio::Tools::Genewise
1229 o Bio::SeqIO now can recongnize sequence formats automatically from
1232 o new parsers in Bio::Tools:
1233 Blat, Geneid, Lagan, Mdust, Promoterwise, PrositeScan,
1235 o Bio::DB::Registry bugs fixed
1236 - BerkeleyDB-indexed flat files can be used by the OBDA system
1237 - Multiple seqdatabase.ini locations in OBDA_SEARCH_PATH are all
1238 used by the OBDA system
1240 o several new HOWTOs
1241 - SimpleWebAnalysis, Trees, Feature Annotation, OBDA Access, Flat
1244 o hundreds of new and improved files
1248 o Bio::Tree::AlleleNode has been updated to be a container of
1249 an Bio::PopGen::Individual object for use in the Coalescent simulations.
1254 1.2.3 Stable release update
1255 o Bug #1475 - Fix and add speedup to spliced_seq for remote location
1257 o Bug #1477 - Sel --> Sec abbreviation fixed
1258 o Fix bug #1487 where paring in-between locations when
1259 end < start caused the FTLocationFactory logic to fail.
1260 o Fix bug #1489 which was not dealing with keywords as an
1261 arrayref properly (this is fixed on the main trunk because
1262 keywords returns a string and the array is accessible via
1264 o Bio::Tree::Tree memory leak (bug #1480) fixed
1265 Added a new initialization option -nodelete which
1266 won't try and cleanup the containing nodes if this
1268 o Bug with parsing labeled nodes with Bio::TreeIO::newick fixed
1269 this was only present on the branch for the 1.2.1 and 1.2.2 series
1270 - Also merged main trunk changes to the branch which make
1271 newick -> nhx round tripping more effective (storing branch length
1272 and bootstrap values in same locate for NodeNHX and Node
1273 implementations.) Fixes to TreeIO parsing for labeled internal
1274 also required small changes to TreeIO::nhx. Improved
1275 tests for this module as well.
1277 - Fixed bugs in BLAST parsing which couldn't parse NCBI
1278 gapped blast properly (was losing hit significance values due to
1279 the extra unexpeted column).
1280 - Parsing of blastcl3 (netblast from NCBI) now can handle case of
1281 integer overflow (# of letters in nt seq dbs is > MAX_INT)
1282 although doesn't try to correct it - will get the negative
1283 number for you. Added a test for this as well.
1284 - Fixed HMMER parsing bug which prevented parsing when a hmmpfam report
1285 has no top-level family classification scores but does have scores and
1286 alignments for individual domains.
1287 - Parsing FASTA reports where ungapped percent ID is < 10 and the
1288 regular expression to match the line was missing the possibility of
1289 an extra space. This is rare, which is why we probably did not
1291 - BLAST parsing picks up more of the statistics/parameter fields
1292 at the bottom of reports. Still not fully complete.
1293 - SearchIO::Writer::HTMLResultWriter and TextResultWriter
1294 were fixed to include many improvements and added flexiblity
1295 in outputting the files. Bug #1495 was also fixed in the process.
1297 - Update for GFF3 compatibility.
1298 - Added scripts for importing from UCSC and GenBank.
1299 - Added a 1.2003 version number.
1302 - Added a 1.2003 version number.
1303 o SeqIO::swiss Bug #1504 fixed with swiss writing which was not
1304 properly writing keywords out.
1305 o Bio::SeqIO::genbank
1306 - Fixed bug/enhancement #1513 where dates of
1307 the form D-MMM-YYYY were not parsed. Even though this is
1308 invalid format we can handle it - and also cleanup the date
1309 string so it is properly formatted.
1310 - Bug/enhancement #1517 fixed so that SEGMENT line can be parsed
1311 and written with Genbank format. Similarly bug #1515 is fixed to
1312 parse in the ORIGIN text.
1313 o Bio::SeqIO::fasta, a new method called preferred_id_type allows you
1314 to specify the ID type, one of (accession accession.version
1315 display primary). See Bio::SeqIO::preferred_id_type method
1316 documentation for more information.
1317 o Unigene parsing updated to handle file format changes by NCBI
1319 1.2.2 Stable release update
1321 o A series of bug fixes of the Bio::OntologyIO dagflat-related parsers:
1322 - auto-discover ontology name
1323 - bug in parsing relationships when certain characters are in the term
1324 - fixed hard-coded prefix for term identifiers
1325 - various smaller issues
1327 o Fixed bug in Bio::Annotation::OntologyTerm of not implementing all
1328 of Bio::Ontology::TermI
1330 o brought the OBDA Registry code up to latest specs
1334 - accession number retrieval fixed
1336 o Bio::SearchIO::blast - fix bug #1443 (missing last hits), parse megablast
1338 o Bio::SearchIO::Writer::(HTML|Text)ResultWriter fix bugs #1458,
1339 #1459 which now properly report alignment start/end info
1340 for translated BLAST/FASTA searches.
1342 o Bio::TreeIO::newick can parse labeled internal nodes
1344 o Bio::Tools::BPbl2seq can properly report strand info for HSPs
1345 for BLASTX if if you provide -report_type => 'BLASTX' when
1346 initializing a BPbl2seq object. Bioperl 1.3 will have better
1347 support for bl2seq in the SearchIO system.
1349 o Bio::Root::IO support a -noclose boolean flag which will not
1350 close a filehandle upon object cleanup - useful when sharing
1351 a filehandle among objects. Additionally code added s.t.
1352 STDOUT/STDIN/STDERR will never be closed by Root::IO cleanup.
1354 o Bio::Tools::Genemark bug #1435 fixed which was missing last prediction
1356 o Bio::SeqIO::genbank
1357 - bug #1456 fixed which generated extra sequence lines
1358 - write moltype correctly for genpept
1360 1.2.1 Stable release update
1362 o Inclusion of WrapperBase, a needed component for StandAloneBlast
1364 o Addition from main trunk of Ontology objects, principly to allow
1365 BioSQL releases against 1.2.1
1367 o Fixes and cleanup of Bio::Coordinate modules
1369 o A fix to Bio::Index::EMBL allowing retrieval of entries using
1370 the primary accession number
1372 o Other bug fixes, including bpindex GenBank fix
1374 o Bio::SeqIO::genbank bug #1389 fixed
1376 1.2 Stable major release
1378 o More functionality added to Bio::Perl, the newbie module
1380 o Bug fixes in Bio::TreeIO::newick fixes bug introduced in 1.0.2
1381 Support for New Hampshire Extended (NHX) format parsing.
1383 o Bio::Tools added support for parsing Genomewise, Pseudowise, Est2Genome,
1384 Tmhmm, SignalP, Seg, RepeatMasker, FootPrinter, and a lightweight
1387 o New ontology parsing Bio::Ontology
1389 o Bug fixes in Bio::SearchIO for HMMer parsing, support for
1390 multi-report (mlib) fasta reports, support for waba and exonerate.
1392 o Bio::ClusterIO for parsing Unigene clusters
1394 o Bio::Assembly added for representing phrap and ace assembly clusters.
1396 o Rudimentary support for writing Chado XML (see
1397 GMOD project: www.gmod.org for more information)
1399 o Bio::Coordinate for mapping between different coordinate systems such
1400 as protein -> cDNA -> Exon -> DNA and back. Useful for mapping
1401 features into different coordinate systems.
1403 o Bio::DB::GenBank/Bio::DB::GenPept now support Entrez queries
1404 with the get_Stream_by_query method and supports the latest
1405 NCBI eutils interface.
1407 o Bugs fixed in Bio::SeqFeature::Collection an in-memory fast
1408 object for extracting subsets of features : currently only
1409 supports extraction by location.
1411 1.1.1 Developer release
1413 o Deprecated modules are now listed in the DEPRECATED file
1415 o New HowTo documents located in doc/howto describing
1416 a domain of Bioperl.
1418 o Note that bugs are now stored at redmine.open-bio.org/projects/bioperl/
1419 and all old bugs are searchable through the bugzilla interface.
1421 o Several reported bugs in Bio::Tools::Sigcleave and Bio::SimpleAlign
1422 have been addressed.
1424 o Support for Genewise parsing in Bio::Tools::Genewise
1426 o Start of Ontology framework with Bio::Ontology
1428 o Speedup to the Bio::Root::Root object method _rearrange.
1429 A global _load_module method was implemented to simplify the
1430 dynamic loading of modules ala Bio::SeqIO::genbank. This
1431 method is now used by all the XXIO (AlignIO,TreeIO,SearchIO,SeqIO,
1434 o Several performance improvements to sequence parsing in Bio::SeqIO.
1435 Attempt to speedup by reducing object creation overhead.
1437 o Bio::DB::GenBank and Bio::DB::GenPept use the NCBI's approved
1438 method for sequence retrieval with their E-utils CGI scripts.
1439 More work to support Entrez queries to their fullest is planned
1442 o Numerous fixes to Bio::SearchIO and sequence parsing (swissprot)
1444 1.1 Developer release
1446 o Bio::Tools::Run has been broken off into a new pkg bioperl-run,
1447 this separation removes some of the complexity in our test suite
1448 and separates the core modules in bioperl from those that need
1449 external programs to run.
1451 o With latest ExtUtils::MakeMaker module installed SGI/IRIX should
1452 not run into trouble running the makefile
1454 o Bio::Location and Bio::SeqIO::FTHelper are fixed to properly
1455 read,create,and write locations for grouped/split locations
1456 (like mRNA features on genomic sequence).
1458 o Bio::Tools::Phlyo added for wrappers for parsing Molphy (protml)
1459 and PAML (codeml,aaml, etc) parsing.
1461 o Bio::Tree:: objects expanded to handle testing monophyly,
1462 paraphyly, least common ancestor, etc.
1464 o Bio::Coordinate for mapping locations from different coordinate spaces
1466 o Bio::SearchIO::waba added for parsing WABA, Bio::SearchIO::hmmer
1467 added for parsing hmmpfam and hmmsearch output.
1469 o Bio::SearchIO::Writer::TextResultWriter for outputting
1470 a pseudo-blast textfile format
1473 1.0.2 Bug fix release
1475 o Note: The modules Bio::DB::GenBank and Bio::DB::GenPept provided
1476 in this release will not work after December 2002 when NCBI
1477 shuts off the old Entrez cgi scripts. We have already fixed
1478 on our main development branch and the functionality will be
1479 available in the next stable bioperl release (1.2) slated for
1482 o Numerous parsing bugs in Bio::SearchIO::fasta found through
1483 testset by Robin Emig. These were fixed as was the get_aln
1484 method in Bio::Search::HSP::GenericHSP to handle the extra
1485 context sequence that is provided with a FastA alignment.
1487 o Migrating differences between Bio::Search::XX::BlastXX to
1488 Bio::Search::XX::GenericXX objects. This included mechanism
1489 to retrieve whole list of HSPs from Hits and whole list of Hits from
1490 Results in addition to the current next_XX iterator methods that
1491 are available. Added seq_inds() method to GenericHSP which identifies
1492 indexes in the query or hit sequences where conserved,identical,gaps,
1493 or mismatch residues are located (adapted from Steve Chervitz's
1494 implementation in BlastHSP).
1496 o Bio::DB::GFF bugs fixed and are necessary for latest GBrowse release.
1497 Bio::DB::GFF::RelSegment is now Bio::SeqI compliant.
1499 o Bio::Graphics glyph set improved and extended for GBrowse release
1501 o Bio::Tree::Tree get_nodes implementation improvement thanks
1502 to Howard Ross notice performance problem when writing out
1505 o Bio::Location::Fuzzy::new named parameter -loc_type became
1506 -location_type, Bio::Location::Simple::new named parameter
1507 -seqid becamse -seq_id.
1509 o Fixed major Bio::AlignIO::emboss parsing bug on needle output,
1510 was mis-detecting that gaps should be placed at the beginning of
1511 the alignment when the best alignment starts internally in the
1514 1.0.1 Bug fix release
1516 o Minor bug fixes to Bio::DB:GFF. Glyph sets improved.
1518 o Parser fixes in SearchIO blast, fasta for more complete WU BLAST
1519 and mixed (3.3 - 3.4) versions of FASTA.
1521 o Small API change to add methods for completeness across
1522 implementations of Bio::Search objects. These new methods
1523 in the interface are implemented by the GenericXX object as well
1524 as the BlastXX objects.
1525 * Bio::Search::Result::ResultI
1526 - hits() method returns list of all Hits (next_hit is an
1529 * Bio::Search::Hit::HitI
1530 - hsps() method returns list of all HSPs (next_hsp is an
1533 o The Bio::SearchIO::Writer classes have been fixed to handle results
1534 created from either psiblast (Search::BlastXX objects) or
1535 blast|fasta|blastxml objects (Search::GenericXX objects). More work
1536 has to be done here to make it work properly and will nee major
1539 o Bugs in Bio::Tools::HMMER fixed, including
1540 * #1178 - Root::IO destructor wasn't being called
1541 * #1034 - filter_on_cutoff now behaves properly
1543 o Bio::SeqFeature::Computation initialization args fixed and
1546 o Tests are somewhat cleaner, flat.t now properly cleans up after itsself,
1548 o Updated FAQ with more example based answers to typical questions
1550 o Bug #1202 was fixed which would improperly join together qual values
1551 parsed by Bio::SeqIO::qual when a trailing space was not present before
1554 1.0.0 Major Stable Release
1556 This represents a major release of bioperl with significant
1557 improvements over the 0.7.x series of releases.
1559 o Bio::Tools::Blast is officially deprecated. Please see
1560 Bio::SearchIO for BLAST and FastA parsing.
1562 o The methods trunc() and subseq() in Bio::PrimarySeqI now accepts
1563 Bio::LocationI objects as well as start/end.
1565 o Bio::Biblio contains modules for Bibliographic data.
1566 Bio::DB::Biblio contains the query modules. Additionally one can
1567 parse medlinexml from the ebi bibliographic query service (BQS)
1568 system and Pubmed xml from NCBI. See Martin Senger's
1569 documentation in Bio::Biblio for more information.
1571 o Bio::DB::Registry is a sequence database registry part of
1572 Open Bioinformatics Database Access. See
1573 http://obda.open-bio.org for more information.
1575 o File-based and In-Memory Sequence caching is provided by
1576 Bio::DB::InMemoryCache and Bio::DB::FileCache which acts like a
1579 o Bio::Graphics for rendering sequences as PNG,JPG, or GIFs has
1580 been added by Lincoln Stein.
1582 o XEMBL SOAP service access in provided in Bio::DB::XEMBL.
1584 o A FAQ has been started and is included in the release to provide
1585 a starting point for frequent questions and issues.
1587 0.9.3 Developer's release
1589 o Event based parsing system improved (SearchIO). With parsers for
1590 XML Blast (blastxml), Text Blast (blast), and FASTA results (fasta).
1591 Additionally a lazy parsing system for text and html blast reports was
1592 added and is called psiblast (name subject to change in future releases).
1594 o Bio::Search objects improved and standardized with associated Interfaces
1595 written. The concept of a search "Hit" was standardized to be called
1596 "hit" consistently and the use of "subject" was deprecated in all active
1599 o Bio::Structure added (since 0.9.1) for Protein structure objects
1600 and PDB parser to retrieve and write these structures from data files.
1602 o Several important Bio::DB::GFF bug fixes for handling features that
1603 are mapped to multiple reference points. Updated mysql adaptor
1604 so as to be able to store large (>100 megabase) chunks of DNA into
1605 Bio::DB::GFF databases.
1607 0.9.2 Developer's release
1609 o Bio::Search and Bio::SearchIO system introduced for event based
1610 parsing of Blast,Fasta reports Bio::SearchIO supports ncbi BLAST
1611 in text and XML and FASTA reports in standard output format.
1613 o Bio::Tree and Bio::TreeIO for phylogenetic trees. A Random tree
1614 generator is included in Bio::TreeIO::RandomTrees and a
1615 statistics module for evaluating.
1617 o Bio::DB::GFF, Lincoln Stein's GFF database suitable as a DB
1618 server for DAS servers.
1620 o Bio::Tools::BPlite is provides more robust parsing of BLAST
1621 files. The entire BPlite system migrated to using Bio::Root::IO
1622 for the data stream.
1624 o Bio::Tools::Alignment for Consed and sequence Trimming
1627 o Bio::Structure for Protein structure information and parsing
1629 o Bio::DB::GenBank/Bio::DB::GenPept updated to new NCBI Entrez
1630 cgi-bin entry point which should be more reliable.
1632 o Bio::Map and Bio::MapIO for biological map navigation and a
1633 framework afor parsing them in. Only preliminary work here.
1635 o Interface for executing EMBOSS programs locally in Bio::Factory::EMBOSS
1636 Future work will integrate Pise and allow submission of analysis on
1639 o Bio::AnnotationCollectionI and Bio::Annotation::Collection
1640 introduced as new objects for handling Sequence Annotation
1641 information (dblinks, references, etc) and is more robust that
1644 o Bio::Tools::FASTAParser introduced.
1646 o Scripts from the bioperl script submission project and new
1647 scripts from bioperl authors are included in "scripts" directory.
1649 o Factory objects and interfaces are being introduced and are more
1652 o Bio::Root::Root introduced as the base object while
1653 Bio::Root::RootI is now simply an interface.
1655 o Bio::DB::RefSeq provides database access to copy of the NCBI
1656 RefSeq database using the EBI dbfetch script.
1658 0.9.0 Developer's release
1660 o perl version at least 5.005 is now required instead of perl 5.004
1662 o Bio::Tools::Run::RemoteBlast is available for running remote
1665 o Bio::Tools::BPbl2seq was fixed to handle multiple HSPs.
1667 o Bio::SeqFeature::GeneStructure migrated to Bio::SeqFeature::Gene.
1668 Also added are related modules UTR3, UTR5, Exon, Intron,
1669 Promotor, PolyA and Transcript.
1671 o Speedup of translate method in PrimarySeq
1673 o Bio::SimpleAlign has new methods: location_from_column(), slice(),
1674 select(), dot(), get_seq_by_pos(), column_from_residue_number()
1676 o Various fixes to Variation toolkit
1678 o Bio::DB::EMBL provides database access to EMBL sequence data.
1679 Bio::DB::Universal provides a central way to point to indexes
1680 and dbs in a single interface.
1682 o Bio::DB::GFF - a database suitable for running DAS servers locally.
1684 o Bio::Factory::EMBOSS is still in design phase as is
1685 Bio::Factory::ApplicationFactoryI
1687 o Dia models for bioperl design are provided in the models/ directory
1689 0.7.2 Bug fix release
1691 o documentation fixes in many modules - SYNOPSIS code verified
1692 to be runnable in many (but not all modules)
1694 o corrected MANIFEST file from 0.7.1 release
1696 o Bug fix in Bio::SeqIO::FTHelper to properly handle
1699 o Bio::SeqIO::genbank
1700 * Correct parsing and writing of genbank format with protein data
1701 * moltype and molecule separation
1703 o Bio::SeqIO::largefasta fix to avoid inifinite loops
1705 o Bio::SimpleAlign fixed to correctly handle consensus
1706 sequence calculation
1708 o Bio::Tools::HMMER supports hmmer 2.2g
1710 o Bio::Tools::BPlite to support report type specific parsing. Most
1711 major changes are not on the 0.7 branch.
1713 o Bio::Tools::Run::StandAloneBlast exists_blast() fixed and works
1716 o Bio::Variation::AAChange/RNAChange corrected labels and mutated alleles
1717 in several types of mutations:
1718 1.) AA level: deletion, complex
1719 2.) AA level: complex, inframe
1720 3.) RNA level: silent
1722 o BPbl2seq parsing of empty reports will not die, but will return
1723 a valid, empty, Bio::SeqFeature::SimilarityFeature for
1724 $report->query() and $report->subject() methods. So an easy
1725 way to test if report was empty is to see if
1726 $report->query->seqname is undefined.
1728 0.7.1 Bug fix release
1730 o Better parsing of genbank/EMBL files especially fixing bugs
1731 related to Feature table parsing and locations on remote
1732 sequences. Additionally, species name parsing was better.
1734 o Bio::SeqIO::genbank can parse now NCBI produced genbank database
1735 which include a number of header lines.
1737 o More strict genbank and EMBL format writing (corrected number of
1738 spaces where appropriate).
1740 o Bio::Tools::BPlite can better parse BLASTX reports - see BUGS
1741 for related BPlite BUGS that are unresolved in this release.
1743 o Bio::DB::GenBank, Bio::DB::GenPept have less problems
1744 downloading sequences from NCBI via HTTP. Bio::DB::SwissProt can
1745 use expasy mirrors or EBI dbfetch cgi-script.
1747 o A moderate number of documentation improvements were made as
1748 well to provide a better code synopsis in each module.
1751 0.7 Large number of changes, including refactoring of the
1752 Object system, new parsers, new functionality and
1753 all round better system. Highlights are:
1756 o Refactored root of inheritance: moved to a lightweight Bio::Root::RootI;
1757 Bio::Root::IO for I/O and file/handle capabilities.
1759 o Imported BPlite modules from Ian Korf for BLAST
1760 parsing. This is considered the supported BLAST parser;
1761 Bio::Tools::Blast.pm will eventually phase out due to lack of support.
1763 o Improved Sequence Feature model. Added complete location
1764 modelling (with fuzzy and compound locations). See
1765 Bio::LocationI and the modules under Bio/Location. Added
1766 support in Genbank/EMBL format parsing to completely parse
1767 feature tables for complex locations.
1769 o Moved special support for databanks etc to specialized modules under
1770 Bio/Seq/. One of these supports very large sequences through
1771 a temporary file as a backend.
1773 o Explicit Gene, Transcript and Exon SeqFeature objects, supporting
1774 CDS retrieval and exon shuffling.
1776 o More parsers: Sim4, Genscan, MZEF, ESTScan, BPbl2seq, GFF
1778 o Refactored Bio/DB/GenBank+GenPept. There is now also DB/SwissProt and
1779 DB/GDB (the latter has platform-specific limitations).
1781 o New analysis parser framework for HT sequence annotation (see
1782 Bio::SeqAnalysisParserI and Bio::Factory::SeqAnalysisParserFactory)
1784 o New Alignment IO framework
1786 o New Index modules (Swissprot)
1788 o New modules for running Blast within perl
1789 (Bio::Tools::Run::StandAloneBlast). Added modules for running
1790 Multiple Sequence Alignment tools ClustalW and TCoffee
1791 (Bio::Tools::Run::Alignment).
1793 o New Cookbook-style tutorial (see bptutorial.pl). Improved
1794 documentation across the package.
1796 o Much improved cross platform support. Many known incompatibilities
1797 have been fixed; however, NT and Mac do not work across the entire
1798 setup (see PLATFORMS).
1800 o Many bug fixes, code restructuring, etc. Overall stability and
1801 maintainability benefit a lot.
1803 o A total of 957 automatic tests
1808 There are very few functionality changes but a large
1809 number of software improvements/bug fixes across the package.
1811 o The EMBL/GenBank parsing are improved.
1813 o The Swissprot reading is improved. Swissprot writing
1814 is disabled as it doesn't work at all. This needs to
1815 wait for 0.7 release
1817 o BLAST reports with no hits are correctly parsed.
1819 o Several other bugs of the BLAST parser (regular expressions, ...)
1822 o Old syntax calls have been replaced with more modern syntax
1824 o Modules that did not work at all, in particular the Sim4
1825 set have been removed
1827 o Bio::SeqFeature::Generic and Bio::SeqFeature::FeaturePair
1828 have improved compliance with interface specs and documentation
1830 o Mailing list documentation updated throughout the distribution
1832 o Most minor bug fixes have happened.
1834 o The scripts in /examples now work and have the modern syntax
1835 rather than the deprecated syntax
1838 0.6.1 Sun April 2 2000
1840 o Sequences can have Sequence Features attached to them
1841 - The sequence features can be read from or written to
1842 EMBL and GenBank style flat files
1844 o Objects for Annotation, including References (but not
1845 full medline abstracts), Database links and Comments are
1848 o A Species object to represent nodes on a taxonomy tree
1851 o The ability to parse HMMER and Sim4 output has been added
1853 o The Blast parsing has been improved, with better PSI-BLAST
1854 support and better overall behaviour.
1856 o Flat file indexed databases provide both random access
1857 and sequential access to their component sequences.
1859 o A CodonTable object has been written with all known
1860 CodonTables accessible.
1862 o A number of new lightweight analysis tools have been
1863 added, such as molecular weight determination.
1865 The 0.6 release also has improved software engineering
1867 o The sequence objects have been rewritten, providing more
1868 maintainable and easier to implement objects. These
1869 objects are backwardly compatible with the 0.05.1 objects
1871 o Many objects are defined in terms of interfaces and then
1872 a Perl implementation has been provided. The interfaces
1873 are found in the 'I' files (module names ending in 'I').
1875 This means that it is possible to wrap C/CORBA/SQL access
1876 as true "bioperl" objects, compatible with the rest of
1879 o The SeqIO system has been overhauled to provide better
1880 processing and perl-like automatic interpretation of <>
1883 o Many more tests have been added (a total of 172 automatic
1884 tests are now run before release).
1888 0.05.1 Tue Jun 29 05:30:44 1999
1889 - Central distribution now requires Perl 5.004. This was
1890 done to get around 5.003-based problems in Bio/Index/*
1892 - Various bug fixes in the Bio::Tools::Blast modules
1893 including better exception handling and PSI-Blast
1894 support. See Bio/Tools/Blast/CHANGES for more.
1895 - Fixed the Parse mechanism in Seq.pm to use readseq.
1896 Follow the instructions in README for how to install
1897 it (basically, you have to edit Parse.pm).
1898 - Improved documentation of Seq.pm, indicating where
1899 objects are returned and where strings are returned.
1900 - Fixed uninitialized warnings in Bio::Root::Object.pm
1901 and Bio::Tools::SeqPattern.pm.
1902 - Bug fixes for PR#s: 30,31,33-35,41,42,44,45,47-50,52.
1904 0.05 Sun Apr 25 01:14:11 1999
1905 - Bio::Tools::Blast modules have less memory problems
1906 and faster parsing. Webblast uses LWP and supports
1907 more functionality. See Bio/Tools/Blast/CHANGES for more.
1908 - The Bio::SeqIO system has been started, moving the
1909 sequence reformatting code out of the sequence object
1910 - The Bio::Index:: system has been started, providing
1911 generic index capabilities and specifically works for
1912 Fasta formatted databases and EMBL .dat formatted
1914 - The Bio::DB:: system started, providing access to
1915 databases, both via flat file + index (see above) and
1917 - The scripts/ directory, where industrial strength scripts
1918 are put has been started.
1919 - Many changes - a better distribution all round.
1921 0.04.4 Wed Feb 17 02:20:13 1999
1922 - Bug fixes in the Bio::Tools::Blast modules and postclient.pl
1923 (see Bio::Tools::Blast::CHANGES).
1924 - Fixed a bug in Bio::Tools::Fasta::num_seqs().
1925 - Beefed up the t/Fasta.t test script.
1926 - Small fix in Bio::Seq::type() (now always returns a string).
1927 - Changed Bio::Root::Utilities::get_newline_char() to
1928 get_newline() since it could return more than one char.
1929 - Added $NEWLINE and $TIMEOUT_SECS to Bio::Root::Global.
1930 - Changed default timeout to 20 seconds (was 3).
1931 - Moved lengthy modification notes to the bottom of some files.
1932 - Fixed SimpleAlign write_fasta bug.
1933 - Beefed up SimpleAlign.t test
1935 0.04.3 Thu Feb 4 07:48:53 1999
1936 - Bio::Root::Object.pm and Global.pm now detect when
1937 script is run as a CGI and suppress output that is only
1938 appropriate when running interactively.
1939 - Bio::Root::Err::_set_context() adds name of script ($0).
1940 - Added comments in Bio::Tools::WWW.pm and Bio::Root::Utilities.pm
1941 regarding the use of the static objects via the qw(:obj) tag.
1942 - Fixed the ambiguous reverse calls in Seq.pm and UnivAln.pm to
1943 CORE::reverse, avoiding Perl warnings.
1944 - Bug fixes in Bio::Tools::Blast modules (version 0.074) and
1945 example scripts (see Bio::Tools::Blast::CHANGES).
1946 - examples/seq/seqtools.pl no longer always warns about using
1947 -prot or -nucl command-line arguments; only when using the
1949 - Methods added to Bio::Root::Utilities: create_filehandle(),
1950 get_newline_char(), and taste_file() to generalize filehandle
1951 creation and autodetect newline characters in files/streams
1952 (see bug report #19).
1953 - Bio::Root::IOManager::read() now handles timeouts and uses
1954 Utilities::create_filehandle().
1955 - Bio::Tools::Fasta.pm uses Utilities::get_newline_char() instead
1956 of hardwiring in "\n".
1957 - Bug fixes in the Bio::SimpleAlign and Bio::Tools::pSW
1959 0.04.2 Wed Dec 30 02:27:36 1998
1960 - Bug fixes in Bio::Tools::Blast modules, version 0.073
1961 (see Bio::Tools::Blast::CHANGES).
1962 - Changed reverse calls in Bio/Seq.pm and Bio/UnivAln.pm
1963 to CORE::reverse (prevents ambiguous warnings with 5.005).
1964 - Appending '.tmp.bioperl' to temporary files created by
1965 Bio::Root::Utilities::compress() or uncompress() to
1966 make it easy to identify & cleanup these files as needed.
1967 - Developers: Created CVS branch release-0-04-bug from
1968 release-0-04-1. Before making bug fixes to the 0.04.1 release,
1969 be sure to cvs checkout this branch into a clean area.
1971 0.04.1 Wed Dec 16 05:39:15 1998
1972 - Bug fixes in Bio::Tools::Blast modules, version 0.072
1973 (see Bio::Tools::Blast::CHANGES).
1974 - Compile/SW/Makefile.PL now removes *.o and *.a files
1977 0.04 Tue Dec 8 07:49:19 1998
1978 - Lots of new modules added including:
1979 * Ewan Birney's Bio::SimpleAlign.pm, Bio::Tools::AlignFactory.pm,
1980 and Bio/Compile directory containing XS-linked C code for
1981 creating Smith-Waterman sequence alignments from within Perl.
1982 * Steve Chervitz's Blast distribution has been incorporated.
1983 * Georg Fuellen's Bio::UnivAln.pm for multiple alignment objects.
1984 - Bio/examples directory for demo scripts for all included modules.
1985 - Bio/t directory containing test suit for all included modules.
1986 - For changes specific to the Blast-related modules prior to
1987 incorporation in this central distribution, see the CHANGES
1988 file in the Bio/Tools/Blast directory.
1990 0.01 Tue Sep 8 14:23:22 1998
1991 - original version from central CVS tree; created by h2xs 1.18